Recombinant Human KPNA5 protein (Tagged)
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Recombinant Human KPNA5 protein (Tagged) is a Human Full Length protein, in the 1 to 536 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
Importin subunit alpha-6, Karyopherin subunit alpha-5, KPNA5
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
KPNA5 is important in the transportation of proteins across the nuclear envelope a process that regulates many cellular functions such as cell division signal transduction and transcriptional control. KPNA5 as part of the importin alpha/beta complex regulates the import of proteins like transcription factors and tumor suppressors into the nucleus. The efficient functioning of this complex ensures proper cellular responses and maintenance of cellular homeostasis. By controlling the nuclear-cytoplasmic transport KPNA5 facilitates the precise localization of proteins necessary for normal cell function.
Pathways
KPNA5 is involved in the nuclear transport pathway and is closely associated with the nucleocytoplasmic transport pathway. It interacts with proteins such as importin beta1 for translocation through the nuclear pore complex. This interaction is essential for processes like the regulation of gene expression and signal-dependent nuclear import which are critical for maintaining cellular activities and responses. The precise regulation of these pathways ensures that cells respond appropriately to different physiological signals and stresses.
Specifications
Form
Liquid
Additional notes
ab199581 was refolded using a unique temperature shift inclusion body refolding technology and chromatographically purified.
General info
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Sequence similarities
Belongs to the importin alpha family.
Target data
Complementary Products
Product promise
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