JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276720

Recombinant Human KREMEN1 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human KREMEN1 protein (His tag) is a Human Fragment protein, in the 1 to 394 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

KREMEN, KRM1, KREMEN1, Kremen protein 1, Dickkopf receptor, Kringle domain-containing transmembrane protein 1, Kringle-containing protein marking the eye and the nose

1 Images
SDS-PAGE - Recombinant Human KREMEN1 protein (His tag) (AB276720)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human KREMEN1 protein (His tag) (AB276720)

SDS-PAGE analysis of ab276720

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96MU8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGSNSWAPPMGAGSHRVEGWT","proteinLength":"Fragment","predictedMolecularWeight":"42.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":394,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96MU8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KREMEN1 also known as Kringle Containing Transmembrane Protein 1 is a transmembrane protein with a mass of approximately 56 kDa. It acts as a receptor involved in the regulation of the Wnt-signaling pathway. This protein participates in modulating cellular functions and development. KREMEN1 expression occurs in various tissues with significant presence noted in the brain kidney and lung. Its role as an antagonist in the pathway marks its importance in maintaining cellular homeostasis.
Biological function summary

KREMEN1 interacts critically with other components of the Wnt pathway such as Dickkopf-1 (DKK1) to mediate cellular signaling. These interactions form a receptor complex with Lipoprotein receptor-related protein 6 (LRP6) which plays a significant role in inhibiting Wnt/beta-catenin signaling. This inhibition is important for processes such as cell differentiation and proliferation. KREMEN1's involvement in these processes highlights its contribution to controlling cellular behavior.

Pathways

KREMEN1 participates primarily in the Wnt signaling pathway. It regulates this pathway by affecting the LRP6 co-receptor in conjunction with DKK1. Another significant pathway involving KREMEN1 is the bone morphogenetic protein (BMP) signaling pathway. Here its interactions illustrate a complex interplay with proteins like noggin and chordin contributing to embryo development and bone formation processes.

Alterations in KREMEN1 expression or function can relate to cancer and bone disorders. In cancers aberrant Wnt signaling often facilitated through dysregulation of KREMEN1 and DKK1 interaction contributes to tumor development and progression. Bone developmental disorders such as osteoporosis may arise from disruptions in KREMEN1's role in bone morphogenetic protein pathways. Understanding KREMEN1's connection with these conditions proves important in therapeutic development and research.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.

style
left-column

Product protocols

style
left-column

Target data

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
See full target information KREMEN1
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB211285

Anti-KREMEN1 antibody - C-terminal

Western blot - Anti-KREMEN1 antibody - C-terminal (AB211285)

  • 5
  • 1
Primary Antibodies

AB15251

Anti-Wnt1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Wnt1 antibody (AB15251)

  • 5
  • 8
Primary Antibodies

AB216347

Anti-SNAIL antibody [EPR21043]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-SNAIL antibody [EPR21043] (AB216347)

  • 1
  • 1
Primary Antibodies

AB32572

Anti-beta Catenin antibody [E247] - ChIP Grade

BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [E247] - ChIP Grade (AB32572)

  • 5
  • 75

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com