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AB158935

Recombinant Human l-Myc protein (GST tag N-Terminus)

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Recombinant Human l-Myc protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 206 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BHLHE38, LMYC, MYCL1, MYCL, Protein L-Myc, Class E basic helix-loop-helix protein 38, Protein L-Myc-1, V-myc myelocytomatosis viral oncogene homolog, bHLHe38

1 Images
SDS-PAGE - Recombinant Human l-Myc protein (GST tag N-Terminus) (AB158935)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human l-Myc protein (GST tag N-Terminus) (AB158935)

ab158935 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P12524

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLGPGAGDPAPGIGPPEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFSARERLERAVSDRLAPGAPRGNPPKASAAPDCTPSLEAGNPAPAAPCPLGEPKTQACSGSESPSDSGKDLPEPSKRGPPHGWPKLCPCLRSGIGSSQALGPSPPLFG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":206,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P12524","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The l-Myc protein also known as L-Myc1 or LMyc is a member of the Myc family of transcription factors. It has a molecular weight around 39 kDa. Researchers find this protein expressed in various tissues but most often in neural and small cell lung cancer (SCLC) cells. As part of its mechanical function l-Myc binds to DNA at specific sequences regulating transcription of target genes involved in cell proliferation and differentiation.
Biological function summary

L-Myc plays a role in modulating cellular processes by forming dimer complexes with other proteins such as Max. In these complexes l-Myc influences the expression of genes linked to cell cycle control metabolism and growth signals. This regulation is essential in maintaining cellular balance and function under normal physiological conditions.

Pathways

L-Myc actively participates in the Myc-Max-Mad network which integrates signals for growth and proliferation. This network associates with important pathways like the MAPK/ERK pathway and the Wnt/β-catenin pathway. In these pathways l-Myc influences cellular responses alongside other Myc proteins like c-Myc and N-Myc which frequently collaborate or have overlapping functions.

L-Myc connects strongly with small cell lung cancer (SCLC) and neuroblastoma. In these cases amplification or overexpression of l-Myc is common often resulting in aggressive tumor growth. The interplay between l-Myc and other Myc family members such as c-Myc highlights their collective role in oncogenic processes driving unchecked cellular proliferation.

Specifications

Form

Liquid

General info

Subcellular localisation

Nucleus

Product protocols

Product promise

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