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AB171590

Recombinant Human L17 protein (His tag N-Terminus)

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Recombinant Human L17 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 300 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C18orf10, HMFN0601, L17, TPGS2, Tubulin polyglutamylase complex subunit 2, PGs2

1 Images
SDS-PAGE - Recombinant Human L17 protein (His tag N-Terminus) (AB171590)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human L17 protein (His tag N-Terminus) (AB171590)

15% SDS-PAGE analysis of ab171590 at 3µg.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q68CL5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.06% EDTA, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as C18orf10.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPLGSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEASDDQPEKPHFDSRSVIFELDSCNGSGKVCLVYKSGKPALAEDTEIWFLDRALYWHFLTDTFTAYYRLLITHLGLPQWQYAFTSYGISPQAKQWFSMYKPITYNTNLLTEETDSFVNKLDPSKVFKSKNKIVIPKKKGPVQPAGGQKGPSGPSGPSTSSTSKSSSGSGNPTRK","proteinLength":"Full Length","predictedMolecularWeight":"35.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":300,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q68CL5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

L17 also known as ribosomal protein L17 is an important component of the 60S subunit of the eukaryotic ribosome. It has a molecular mass of approximately 22 kDa. L17 is expressed in various tissues throughout the body with particularly high expression levels in rapidly-dividing cells. As a structural element of the large ribosomal subunit L17 plays a role in the core processes of protein synthesis.
Biological function summary

The function of protein L17 involves participation in the formation of the ribosome complex. It interacts with other ribosomal proteins and rRNA molecules to ensure the accurate assembly of the ribosome. This assembly allows the ribosomal machinery to facilitate efficient translation of mRNA into polypeptides which are subsequently folded into functional proteins essential for cellular functions and proliferation.

Pathways

The protein L17 engages with translation-related pathways notably the ribosomal biogenesis pathway and the mTOR signaling pathway. The mTOR pathway regulates cell growth and metabolism in response to nutrients stress and growth factors. As part of the ribosome L17 indirectly associates with proteins like RPL5 and RPL11 essential for ribosome biogenesis and function forming a link between ribosome assembly and cellular regulation.

Ribosomal protein L17 has implications in ribosomopathies such as Diamond-Blackfan Anemia which is characterized by impaired ribosome biogenesis and function. Mutations affecting L17 and its associated proteins such as RPL5 and RPL11 can disrupt normal ribosomal biogenesis leading to developmental abnormalities and increased susceptibility to specific cancers due to the imbalance in protein synthesis and cellular homeostasis.
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Specifications

Form

Liquid

Additional notes

ab171590 was purified using conventional chromatography.

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General info

Function

Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.
See full target information TPGS2
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Complementary Products

Cell Lines & Lysates

AB265398

Human TPGS2 (L17) knockout HeLa cell line

Sanger Sequencing - Human TPGS2 (L17) knockout HeLa cell line (AB265398)

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Cell Lines & Lysates

AB263397

Human TPGS2 (L17) knockout HeLa cell lysate

Sanger Sequencing - Human TPGS2 (L17) knockout HeLa cell lysate (AB263397)

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Primary Antibodies

AB254850

Anti-L17 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L17 antibody (AB254850)

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