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AB151896

Recombinant Human LACTB2 protein

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Recombinant Human LACTB2 protein is a Human Full Length protein, in the 1 to 288 aa range, expressed in Escherichia coli, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

CGI-83, LACTB2, Endoribonuclease LACTB2, Beta-lactamase-like protein 2

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 0.1 EU/µg

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q53H82

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride, 0.03% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL","proteinLength":"Full Length","predictedMolecularWeight":"32.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q53H82","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LACTB2 also known as lactamase beta 2 functions primarily as a mitochondrial serine protease. This protein typically exhibits a mass of around 40 kDa. LACTB2 shows expression largely within mitochondrial tissue indicating its specialized function in this cellular environment. The presence in mitochondria connects LACTB2 to cellular processes involving the regulation of protein composition within these organelles.
Biological function summary

The activity of LACTB2 influences mitochondrial morphology and function. Within this context LACTB2 acts as a solitary protein and is not identified as part of a larger protein complex. Through its protease activity LACTB2 participates in the processing of mitochondrial proteins reflecting its role in maintaining protein homeostasis in the mitochondria.

Pathways

Mitochondrial dynamics and oxidative phosphorylation rely on the function of proteins like LACTB2. LACTB2 plays a part in pathways managing mitochondrial quality control including interactions with proteins such as OPA1 and MFN2 that help modulate mitochondrial fusion and fission. These interactions emphasize the vital role LACTB2 has in sustaining mitochondrial integrity and function impacting energy production and cellular stress responses.

LACTB2 has associations with various mitochondrial disorders and neurodegenerative diseases such as Alzheimer's disease. The function of LACTB2 affects the stability and function of proteins like amyloid precursor protein (APP) which is linked to Alzheimer's pathology. Understanding these relationships highlights the importance of LACTB2 in neurological health and disease where dysfunctions in mitochondrial processes occur frequently.
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Specifications

Form

Liquid

Additional notes

ab151896 is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Subcellular localisation

Mitochondrion matrix

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Product protocols

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Target data

Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
See full target information LACTB2
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