Recombinant Human LAGE3 protein
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Recombinant Human LAGE3 protein is a Human Full Length protein, in the 1 to 143 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
DXS9879E, ESO3, ITBA2, LAGE3, EKC/KEOPS complex subunit LAGE3, L antigen family member 3, Protein ESO-3, Protein ITBA2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human LAGE3 protein (AB156727)
15% SDS-PAGE analysis of ab156727 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LAGE3 fits into the tRNA modification complex where it enhances the modification of tRNA molecules. This role is important for maintaining correct protein synthesis as it ensures proper codon recognition and translation fidelity. LAGE3 pairs with other proteins to form a functional complex that effectively influences translational precision during protein production.
Pathways
LAGE3 actively contributes to the tRNA modification pathway and is linked with the protein translation process. Its association with the KEOPS/EKC complex indicates interactions with proteins like OSGEP and TP53RK both involved in maintaining cellular translational processes. These connections illustrate its importance in ensuring accurate protein assembly.
Specifications
Form
Liquid
Additional notes
ab156727 is purified using conventional chromatography techniques (anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA).
General info
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed : 22912744, PubMed : 27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed : 22912744, PubMed : 27903914). LAGE3 functions as a dimerization module for the complex (PubMed : 22912744, PubMed : 27903914).
Sequence similarities
Belongs to the CTAG/PCC1 family.
Subcellular localisation
Nucleus
Target data
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Product promise
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