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Recombinant Human LAIR1 protein is a Human Fragment protein, in the 22 to 125 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human LAIR1 protein (AB51219), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M Q E E D L P R P S I S A E P G T V I P L G S H V T F V C R G P V G V Q T F R L E R E S R S T Y N D T E D V S Q A S P S E S E A R F R I D S V S E G N A G P Y R C I Y Y K P P K W S E Q S D Y L E L L V K E T S G

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Alternative names

Recommended products

Recombinant Human LAIR1 protein is a Human Fragment protein, in the 22 to 125 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
Q6GTX8-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 7.5
Constituents: 0.316% Tris HCl, 0.29% Sodium chloride, 0.0292% EDTA

Sequence info

Amino acid sequence

M Q E E D L P R P S I S A E P G T V I P L G S H V T F V C R G P V G V Q T F R L E R E S R S T Y N D T E D V S Q A S P S E S E A R F R I D S V S E G N A G P Y R C I Y Y K P P K W S E Q S D Y L E L L V K E T S G

Accession

Q6GTX8

Protein length

Fragment

Amino acids

22 to 125

Nature

Recombinant

Specifications

Form

Liquid

Additional notes

The extracellular domain of LAIR 1( 22-125aa) was overexpressed in *E.coli*, and purified by using conventional chromatography techniques.

General info

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Post-translational modifications

Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LAIR1 also known as Leukocyte-Associated Immunoglobulin-like Receptor 1 is a transmembrane protein with a molecular weight of approximately 32 kDa. It expresses mainly on immune cells including T cells B cells and myeloid cells. This receptor by binding to collagen plays a significant role in controlling immune cell signaling. It acts as an inhibitory receptor which helps in maintaining immune system balance and prevents excessive immune responses.

Biological function summary

LAIR1 functions by modulating immune responses and maintaining homeostasis in the immune system. It is a part of a complex pathway involved in inhibitory signaling. When LAIR1 binds to its ligand such as collagen it transduces a signal that reduces activation of immune cells. This inhibition ensures that immune cells do not become overactive which could otherwise lead to tissue damage.

Pathways

LAIR1 participates in immune checkpoint regulation and collagen interaction pathways. It interacts with proteins such as ITIM-containing molecules which transmit inhibitory signals essential for regulating immune cell activation. It also indirectly connects to the TGF-beta signaling pathway which is vital for controlling cell differentiation and immune regulation.

Associated diseases and disorders

LAIR1 is of interest due to its connection to autoimmune diseases and certain cancers. In autoimmune diseases such as rheumatoid arthritis dysregulated LAIR1 signaling may contribute to inflammation. The protein is also linked to cancer where its inhibitory signaling might affect tumor immune evasion. The connection between LAIR1 and these conditions involves proteins like autoimmune-related genes and tumor-associated surface molecules.

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1 product image

  • SDS-PAGE - Recombinant Human LAIR1 protein (ab51219), expandable thumbnail

    SDS-PAGE - Recombinant Human LAIR1 protein (ab51219)

    ab51219 in 14% SDS-PAGE

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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