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Recombinant Human Lamin B Receptor/LBR protein is a Human Full Length protein, in the 1 to 615 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Alternative names=Delta(14)-sterol reductase LBR, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, Integral nuclear envelope inner membrane protein, LMN2R, Lamin-B receptor, Sterol C14-reductase, C14SR, LBR
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
M P S R K F A D G E V V R G R W P G S S L Y Y E V E I L S H D S T S Q L Y T V K Y K D G T E L E L K E N D I K P L T S F R Q R K G G S T S S S P S R R R G S R S R S R S R S P G R P P K S A R R S A S A S H Q A D I K E A R R E V E V K L T P L I L K P F G N S I S R Y N G E P E H I E R N D A P H K N T Q E K F S L S Q E S S Y I A T Q Y S L R P R R E E V K L K E I D S K E E K Y V A K E L A V R T F E V T P I R A K D L E F G G V P G V F L I M F G L P V F L F L L L L M C K Q K D P S L L N F P P P L P A L Y E L W E T R V F G V Y L L W F L I Q V L F Y L L P I G K V V E G T P L I D G R R L K Y R L N G F Y A F I L T S A V I G T S L F Q G V E F H Y V Y S H F L Q F A L A A T V F C V V L S V Y L Y M R S L K A P R N D L S P A S S G N A V Y D F F I G R E L N P R I G T F D L K Y F C E L R P G L I G W V V I N L V M L L A E M K I Q D R A V P S L A M I L V N S F Q L L Y V V D A L W N E E A L L T T M D I I H D G F G F M L A F G D L V W V P F I Y S F Q A F Y L V S H P N E V S W P M A S L I I V L K L C G Y V I F R G A N S Q K N A F R K N P S D P K L A H L K T I H T S T G K N L L V S G W W G F V R H P N Y L G D L I M A L A W S L P C G F N H I L P Y F Y I I Y F T M L L V H R E A R D E Y H C K K K Y G V A W E K Y C Q R V P Y R I F P Y I Y
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Recombinant Human Lamin B Receptor/LBR protein is a Human Full Length protein, in the 1 to 615 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Alternative names=Delta(14)-sterol reductase LBR, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, Integral nuclear envelope inner membrane protein, LMN2R, Lamin-B receptor, Sterol C14-reductase, C14SR, LBR
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
97.1 kDa
1 to 615
M P S R K F A D G E V V R G R W P G S S L Y Y E V E I L S H D S T S Q L Y T V K Y K D G T E L E L K E N D I K P L T S F R Q R K G G S T S S S P S R R R G S R S R S R S R S P G R P P K S A R R S A S A S H Q A D I K E A R R E V E V K L T P L I L K P F G N S I S R Y N G E P E H I E R N D A P H K N T Q E K F S L S Q E S S Y I A T Q Y S L R P R R E E V K L K E I D S K E E K Y V A K E L A V R T F E V T P I R A K D L E F G G V P G V F L I M F G L P V F L F L L L L M C K Q K D P S L L N F P P P L P A L Y E L W E T R V F G V Y L L W F L I Q V L F Y L L P I G K V V E G T P L I D G R R L K Y R L N G F Y A F I L T S A V I G T S L F Q G V E F H Y V Y S H F L Q F A L A A T V F C V V L S V Y L Y M R S L K A P R N D L S P A S S G N A V Y D F F I G R E L N P R I G T F D L K Y F C E L R P G L I G W V V I N L V M L L A E M K I Q D R A V P S L A M I L V N S F Q L L Y V V D A L W N E E A L L T T M D I I H D G F G F M L A F G D L V W V P F I Y S F Q A F Y L V S H P N E V S W P M A S L I I V L K L C G Y V I F R G A N S Q K N A F R K N P S D P K L A H L K T I H T S T G K N L L V S G W W G F V R H P N Y L G D L I M A L A W S L P C G F N H I L P Y F Y I I Y F T M L L V H R E A R D E Y H C K K K Y G V A W E K Y C Q R V P Y R I F P Y I Y
Full Length
No
Recombinant
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Liquid
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963).
Belongs to the ERG4/ERG24 family.
Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin.
Nucleus inner membrane, Nucleus
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was previously labelled as Lamin B Receptor.
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