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Recombinant Human Lamin B Receptor/LBR protein is a Human Full Length protein, in the 1 to 615 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

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Expression system

Wheat germ

Tags

Tag free

Applications

SDS-PAGE, ELISA, WB

Biologically active

No

Sequence

M P S R K F A D G E V V R G R W P G S S L Y Y E V E I L S H D S T S Q L Y T V K Y K D G T E L E L K E N D I K P L T S F R Q R K G G S T S S S P S R R R G S R S R S R S R S P G R P P K S A R R S A S A S H Q A D I K E A R R E V E V K L T P L I L K P F G N S I S R Y N G E P E H I E R N D A P H K N T Q E K F S L S Q E S S Y I A T Q Y S L R P R R E E V K L K E I D S K E E K Y V A K E L A V R T F E V T P I R A K D L E F G G V P G V F L I M F G L P V F L F L L L L M C K Q K D P S L L N F P P P L P A L Y E L W E T R V F G V Y L L W F L I Q V L F Y L L P I G K V V E G T P L I D G R R L K Y R L N G F Y A F I L T S A V I G T S L F Q G V E F H Y V Y S H F L Q F A L A A T V F C V V L S V Y L Y M R S L K A P R N D L S P A S S G N A V Y D F F I G R E L N P R I G T F D L K Y F C E L R P G L I G W V V I N L V M L L A E M K I Q D R A V P S L A M I L V N S F Q L L Y V V D A L W N E E A L L T T M D I I H D G F G F M L A F G D L V W V P F I Y S F Q A F Y L V S H P N E V S W P M A S L I I V L K L C G Y V I F R G A N S Q K N A F R K N P S D P K L A H L K T I H T S T G K N L L V S G W W G F V R H P N Y L G D L I M A L A W S L P C G F N H I L P Y F Y I I Y F T M L L V H R E A R D E Y H C K K K Y G V A W E K Y C Q R V P Y R I F P Y I Y

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Shipping To:
United States

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
ELISA
Reactivity
Reacts
Dilution info
-
Notes

-

Application
WB
Reactivity
Reacts
Dilution info
-
Notes

-

Images

Target data

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Recombinant Human Lamin B Receptor/LBR protein is a Human Full Length protein, in the 1 to 615 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

Key facts

Expression system

Wheat germ

Applications

SDS-PAGE, ELISA, WB

Predicted molecular weight

97.1 kDa

Amino acids

1 to 615

Sequence

M P S R K F A D G E V V R G R W P G S S L Y Y E V E I L S H D S T S Q L Y T V K Y K D G T E L E L K E N D I K P L T S F R Q R K G G S T S S S P S R R R G S R S R S R S R S P G R P P K S A R R S A S A S H Q A D I K E A R R E V E V K L T P L I L K P F G N S I S R Y N G E P E H I E R N D A P H K N T Q E K F S L S Q E S S Y I A T Q Y S L R P R R E E V K L K E I D S K E E K Y V A K E L A V R T F E V T P I R A K D L E F G G V P G V F L I M F G L P V F L F L L L L M C K Q K D P S L L N F P P P L P A L Y E L W E T R V F G V Y L L W F L I Q V L F Y L L P I G K V V E G T P L I D G R R L K Y R L N G F Y A F I L T S A V I G T S L F Q G V E F H Y V Y S H F L Q F A L A A T V F C V V L S V Y L Y M R S L K A P R N D L S P A S S G N A V Y D F F I G R E L N P R I G T F D L K Y F C E L R P G L I G W V V I N L V M L L A E M K I Q D R A V P S L A M I L V N S F Q L L Y V V D A L W N E E A L L T T M D I I H D G F G F M L A F G D L V W V P F I Y S F Q A F Y L V S H P N E V S W P M A S L I I V L K L C G Y V I F R G A N S Q K N A F R K N P S D P K L A H L K T I H T S T G K N L L V S G W W G F V R H P N Y L G D L I M A L A W S L P C G F N H I L P Y F Y I I Y F T M L L V H R E A R D E Y H C K K K Y G V A W E K Y C Q R V P Y R I F P Y I Y

Accession
Q14739-1
Protein length

Full Length

Animal free

No

Nature

Recombinant

Species

Human

Concentration
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Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione

Specifications

Form

Liquid

General info

Function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963).

Sequence similarities

Belongs to the ERG4/ERG24 family.

Post-translational modifications

Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin.

Subcellular localisation

Nucleus inner membrane, Nucleus

Storage

Shipped at conditions

Dry Ice

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This product was previously labelled as Lamin B Receptor.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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