Recombinant Human LAMP2B protein
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Recombinant Human LAMP2B protein is a Human protein, in the 29 to 375 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.
View Alternative Names
CD107b, Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, LGP-96, LAMP2
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LAMP2B facilitates lysosomal fusion with autophagosomes aiding the process of autophagy important for cellular maintenance and survival. It forms part of a complex involved in chaperone-mediated autophagy a specific system of protein degradation. This adaptation prevents intracellular damage with LAMP2B playing a critical role in maintaining cellular homeostasis.
Pathways
Studies indicate that LAMP2B is significantly involved in the autophagy-lysosome pathway. It works alongside key proteins like LC3 and Beclin-1 which drive the formation and function of autophagosomes. Through this LAMP2B influences cellular recycling and energy balance linking it closely to cellular stress response and homeostatic regulations.
Specifications
Form
Lyophilized
Additional notes
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE
General info
Function
The protein expressed by gene LAMP2 plays an important role in chaperone-mediated autophagy, facilitating the lysosomal degradation of proteins in response to various stresses and as part of normal protein turnover, especially for those with a long biological half-life. It functions by binding target proteins like GAPDH and MLLT11, directing them for lysosomal degradation, and is necessary for the fusion of autophagosomes with lysosomes during autophagy. Although cells lacking LAMP2 express normal VAMP8 levels, they fail to accumulate STX17 on autophagosomes, likely explaining the fusion failure between autophagosomes and lysosomes. LAMP2 is essential for the normal degradation of autophagosomal contents and efficient MHCII-mediated presentation of exogenous antigens, as it facilitates lysosomal protein degradation. It is not required for the presentation of endogenous antigens via MHCII. Specifically, isoform LAMP-2C modulates chaperone-mediated autophagy, reduces presentation of endogenous antigens by MHCII, and does not influence the presentation of exogenous and membrane-derived antigens by MHCII. This supplementary information is collated from multiple sources and compiled automatically.
Sequence similarities
Belongs to the LAMP family.
Post-translational modifications
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Subcellular localisation
Endosome membrane
Target data
Complementary Products
Primary Antibodies
AB18528
Anti-LAMP2A antibody - Lysosome Marker
BOND RX™ Validated|Lab Essentials
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Primary Antibodies
AB2900
Anti-EEA1 antibody - Early Endosome Marker
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Product promise
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