Recombinant Human LANCL2 protein is a Human Full Length protein, in the 1 to 450 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M G E T M S K R L K L H L G G E A E M E E R A F V N P F P D Y E A A A G A L L A S G A A E E T G C V R P P A T T D E P G L P F H Q D G K I I H N F I R R I Q T K I K D L L Q Q M E E G L K T A D P H D C S A Y T G W T G I A L L Y L Q L Y R V T C D Q T Y L L R S L D Y V K R T L R N L N G R R V T F L C G D A G P L A V G A V I Y H K L R S D C E S Q E C V T K L L Q L Q R S V V C Q E S D L P D E L L Y G R A G Y L Y A L L Y L N T E I G P G T V C E S A I K E V V N A I I E S G K T L S R E E R K T E R C P L L Y Q W H R K Q Y V G A A H G M A G I Y Y M L M Q P A A K V D Q E T L T E M V K P S I D Y V R H K K F R S G N Y P S S L S N E T D R L V H W C H G A P G V I H M L M Q A Y K V F K E E K Y L K E A M E C S D V I W Q R G L L R K G Y G I C H G T A G N G Y S F L S L Y R L T Q D K K Y L Y R A C K F A E W C L D Y G A H G C R I P D R P Y S L F E G M A G A I H F L S D V L G P E T S R F P A F E L D S S K R D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Alternative names
GPR69B, TASP, LANCL2, LanC-like protein 2, Testis-specific adriamycin sensitivity protein
Recommended products
Recombinant Human LANCL2 protein is a Human Full Length protein, in the 1 to 450 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9NS86-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G E T M S K R L K L H L G G E A E M E E R A F V N P F P D Y E A A A G A L L A S G A A E E T G C V R P P A T T D E P G L P F H Q D G K I I H N F I R R I Q T K I K D L L Q Q M E E G L K T A D P H D C S A Y T G W T G I A L L Y L Q L Y R V T C D Q T Y L L R S L D Y V K R T L R N L N G R R V T F L C G D A G P L A V G A V I Y H K L R S D C E S Q E C V T K L L Q L Q R S V V C Q E S D L P D E L L Y G R A G Y L Y A L L Y L N T E I G P G T V C E S A I K E V V N A I I E S G K T L S R E E R K T E R C P L L Y Q W H R K Q Y V G A A H G M A G I Y Y M L M Q P A A K V D Q E T L T E M V K P S I D Y V R H K K F R S G N Y P S S L S N E T D R L V H W C H G A P G V I H M L M Q A Y K V F K E E K Y L K E A M E C S D V I W Q R G L L R K G Y G I C H G T A G N G Y S F L S L Y R L T Q D K K Y L Y R A C K F A E W C L D Y G A H G C R I P D R P Y S L F E G M A G A I H F L S D V L G P E T S R F P A F E L D S S K R D
- Accession
- Q9NS86
- Protein length
- Full Length
- Amino acids
- 1 to 450
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
- Sequence similarities
Belongs to the LanC-like protein family.
- Post-translational modifications
Myristoylated. Essential for membrane association.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LANCL2 also known as Lanthionine Synthetase C-Like 2 is a protein with a molecular weight of approximately 44 kDa. It belongs to the LANCL protein family which also includes LANCL1 and LANCL3. LANCL2 is expressed in various tissues with significant expression observed in adipose tissue liver and skeletal muscle. Its intracellular location suggests a role in cellular processes that require close interaction with intracellular signaling pathways.
- Biological function summary
LANCL2 functions in regulatory mechanisms related to metabolic processes. It does not exist in isolation; instead it interacts with other proteins as part of a multiprotein complex. LANCL2 modulates the signaling pathway involving the peroxisome proliferator-activated receptor gamma (PPARγ) and plays a role in modulating glucose and lipid metabolism. Its activity suggests involvement in maintaining cellular energy balance and homeostasis.
- Pathways
LANCL2 is integrated into metabolic pathways with significant involvement in both the PPAR signaling pathway and the insulin signaling pathway. These pathways highlight its importance in glucose homeostasis and energy metabolism. LANCL2 interacts with proteins such as AKT an important player in the insulin signaling pathway contributing to the regulation of glucose uptake and lipid metabolism.
- Associated diseases and disorders
LANCL2 has been connected to metabolic diseases particularly type 2 diabetes and obesity. Changes in LANCL2 expression or function can impact glucose and lipid regulation contributing to these conditions. LANCL2's role in these disorders often involves its interaction with proteins like PPARγ which also influences lipid storage and insulin sensitivity. Understanding LANCL2's role in these diseases could provide insights into novel therapeutic approaches.
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1 product image
SDS-PAGE - Recombinant Human LANCL2 protein (ab163277)
ab163277 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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