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AB163277

Recombinant Human LANCL2 protein (GST tag N-Terminus)

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Recombinant Human LANCL2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 450 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

GPR69B, TASP, LANCL2, LanC-like protein 2, Testis-specific adriamycin sensitivity protein

1 Images
SDS-PAGE - Recombinant Human LANCL2 protein (GST tag N-Terminus) (AB163277)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LANCL2 protein (GST tag N-Terminus) (AB163277)

ab163277 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NS86

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

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Western blot - Anti-LANCL2 antibody [EPR27973-132] - BSA and Azide free (AB317445)

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Proteins & Peptides

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Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDCESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYKVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAIHFLSDVLGPETSRFPAFELDSSKRD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":450,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NS86","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LANCL2 also known as Lanthionine Synthetase C-Like 2 is a protein with a molecular weight of approximately 44 kDa. It belongs to the LANCL protein family which also includes LANCL1 and LANCL3. LANCL2 is expressed in various tissues with significant expression observed in adipose tissue liver and skeletal muscle. Its intracellular location suggests a role in cellular processes that require close interaction with intracellular signaling pathways.
Biological function summary

LANCL2 functions in regulatory mechanisms related to metabolic processes. It does not exist in isolation; instead it interacts with other proteins as part of a multiprotein complex. LANCL2 modulates the signaling pathway involving the peroxisome proliferator-activated receptor gamma (PPARγ) and plays a role in modulating glucose and lipid metabolism. Its activity suggests involvement in maintaining cellular energy balance and homeostasis.

Pathways

LANCL2 is integrated into metabolic pathways with significant involvement in both the PPAR signaling pathway and the insulin signaling pathway. These pathways highlight its importance in glucose homeostasis and energy metabolism. LANCL2 interacts with proteins such as AKT an important player in the insulin signaling pathway contributing to the regulation of glucose uptake and lipid metabolism.

LANCL2 has been connected to metabolic diseases particularly type 2 diabetes and obesity. Changes in LANCL2 expression or function can impact glucose and lipid regulation contributing to these conditions. LANCL2's role in these disorders often involves its interaction with proteins like PPARγ which also influences lipid storage and insulin sensitivity. Understanding LANCL2's role in these diseases could provide insights into novel therapeutic approaches.
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Specifications

Form

Liquid

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General info

Function

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Sequence similarities

Belongs to the LanC-like protein family.

Post-translational modifications

Myristoylated. Essential for membrane association.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
See full target information LANCL2
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