JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB161621

Recombinant Human LARS2 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human LARS2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 903 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0028, LARS2, Leucyl-tRNA synthetase, LeuRS

1 Images
SDS-PAGE - Recombinant Human LARS2 protein (GST tag N-Terminus) (AB161621)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human LARS2 protein (GST tag N-Terminus) (AB161621)

ab161621 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q15031

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (AB159886)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

  • 0
  • 0
Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (AB161146)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":903,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15031","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LARS2 also known as mitochondrial leucyl-tRNA synthetase 2 plays a significant role in protein biosynthesis. This enzyme is part of the class II aminoacyl-tRNA synthetase family with a molecular mass of around 108 kDa. LARS2 primarily functions in mitochondria ensuring the proper attachment of leucine to its corresponding tRNA an essential step for protein translation. Expression of LARS2 occurs most notably in tissues with high metabolic demands such as muscle and liver where mitochondrial activity is important.
Biological function summary

LARS2 facilitates the translation of mitochondrial-encoded proteins by charging tRNA with leucine. It operates as a monomer and does not participate in a larger complex. This charging process is essential for maintaining mitochondrial function and energy production ensuring the correct synthesis of respiratory chain components. LARS2 thereby provides support for the translation machinery within mitochondria.

Pathways

LARS2 plays an indispensable role within the mitochondrial translation system. It directly influences the oxidative phosphorylation pathway by enabling the synthesis of components important for electron transport and ATP production. LARS2 interacts functionally with other mitochondrial tRNA synthetases like GARS2 and YARS2 contributing to the efficient translation of proteins fundamental for cellular respiration.

Mutations in the LARS2 gene have been linked to Perrault syndrome a condition characterized by ovarian dysgenesis and sensorineural deafness. Additionally disruptions in LARS2 activity may also contribute to mitochondrial encephalopathy. The dysfunction of LARS2 affects proteins within the mitochondrial oxidative phosphorylation pathway impacting ATP production and cellular energy balance which further associates with disorders involving METTL1 and other mitochondrial synthetases impacting similar processes.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Catalyzes the attachment of leucine to its cognate tRNA.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Subcellular localisation

Mitochondrion matrix

style
left-column

Product protocols

style
left-column

Target data

Catalyzes the attachment of leucine to its cognate tRNA.
See full target information LARS2
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com