Recombinant Human LBH protein is a Human Full Length protein, in the 1 to 105 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S I Y F P I H C P D Y L R S A K M T E V M M N T Q P M E E I G L S P R K D G L S Y Q I F P D P S D F D R C C K L K D R L P S I V V E P T E G E V E S G E L R W P P E E F L V Q E D E Q D N C E E T A K E N K E Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
Alternative names
Protein LBH, hLBH, Limb bud and heart development protein homolog, LBH
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Recombinant Human LBH protein is a Human Full Length protein, in the 1 to 105 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q53QV2-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S I Y F P I H C P D Y L R S A K M T E V M M N T Q P M E E I G L S P R K D G L S Y Q I F P D P S D F D R C C K L K D R L P S I V V E P T E G E V E S G E L R W P P E E F L V Q E D E Q D N C E E T A K E N K E Q
- Accession
- Q53QV2
- Protein length
- Full Length
- Predicted molecular weight
- 14.6 kDa
- Amino acids
- 1 to 105
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab171498 is purified by using conventional chromatography techniques.
General info
- Function
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
- Sequence similarities
Belongs to the LBH family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LBH also known as limb-bud and heart protein is a small protein with an approximate mass of 47 kDa. It plays a critical role in cell signaling and development processes by functioning as a transcriptional regulator impacting gene expression. Researchers discovered LBH's expression in several tissues including limb buds the heart and various epithelial tissues. This suggests its involvement in early developmental stages and tissue differentiation.
- Biological function summary
LBH influences the development of tissues by modulating gene expression during embryonic growth. It operates as part of a transcriptional complex that interacts with other transcription factors and cofactors. The influence of LBH on cellular differentiation aligns with its expression in developing organs suggesting its role in establishing cellular identities and organogenesis.
- Pathways
LBH integrates into signaling pathways related to developmental regulation such as the Wnt signaling pathway and TGF-beta pathway. LBH functions in conjunction with proteins like beta-catenin within the Wnt pathway which is important for cellular proliferation and differentiation. These pathways ensure a coordinated pattern of development linking LBH's activity to broader signaling networks that govern embryogenesis and tissue formation.
- Associated diseases and disorders
Alterations in LBH expression have connections with congenital heart defects and certain cancers illustrating its role in human health. Changes in LBH function or levels may disrupt normal development leading to conditions like atrial septal defects connected to aberrant interactions with transcription factors like T-box proteins. Furthermore its involvement in cancers suggests a link with proteins involved in cell cycle regulation hinting at potential therapeutic targets.
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1 product image
SDS-PAGE - Recombinant Human LBH protein (ab171498)
15% SDS-PAGE analysis of ab171498 (3μg).
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