Recombinant Human LCE3A protein (His tag) is a Human Full Length protein, in the 1 to 89 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S C Q Q N Q Q Q C Q P P P K C P A K S P A Q C L P P A S S S C A P S S G G C G P S S E R S C C L S H H R C R R S H R C R C Q S S N S C D R G S G Q Q G G S S S C G H S S A G C C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).
Alternative names
LEP13, LCE3A, Late cornified envelope protein 3A, Late envelope protein 13
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Recombinant Human LCE3A protein (His tag) is a Human Full Length protein, in the 1 to 89 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q5TA76-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M S C Q Q N Q Q Q C Q P P P K C P A K S P A Q C L P P A S S S C A P S S G G C G P S S E R S C C L S H H R C R R S H R C R C Q S S N S C D R G S G Q Q G G S S S C G H S S A G C C
- Accession
- Q5TA76
- Protein length
- Full Length
- Predicted molecular weight
- 14.6 kDa
- Amino acids
- 1 to 89
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).
- Sequence similarities
Belongs to the LCE family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The late cornified envelope 3A (LCE3A) protein is a member of the LCE3 cluster with a molecular mass of approximately 10 kDa. The LCE3A gene is located on chromosome 1q21 in the epidermal differentiation complex and is expressed highly in the epidermis specifically in the outermost layers of skin. LCE3A features in the formation of the cornified cell envelope which is significant for the barrier function of the skin. This protein supports skin integrity by interacting with structural proteins such as involucrin and loricrin.
- Biological function summary
LCE3A plays an integral role in skin barrier repair and maintenance. It does not appear as part of a larger protein complex but functions with related LCEs to enhance skin resilience. LCE3A is important in rapid response to skin injury where it aids in restoring the protective outer skin layer. The protein's presence ensures a flexible yet robust barrier capable of management of moisture retention and pathogen resistance. This function accentuates its value in maintaining healthy skin physiology.
- Pathways
LCE3A engages in the epidermal development and differentiation pathways. It works closely with structural proteins and enzymes involved in the cornification and keratinization processes like filaggrin and transglutaminases. These pathways enable efficient skin barrier formation and contribute to the dynamic process of skin regeneration. The interconnected roles of these proteins highlight their importance in establishing a competent skin barrier responsive to environmental challenges and repair needs.
- Associated diseases and disorders
LCE3A has a recognized association with psoriasis and potential involvement in other skin-related conditions. LCE3A expression loss or dysfunction links with impaired skin barrier contributing to the development of psoriasis. Related proteins such as LCE3B and LCE3C also contribute to this condition by influencing barrier integrity. Understanding LCE3A's role in skin physiology aids in exploring therapeutic targets for treating or managing psoriasis or similar skin pathologies.
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1 product image
SDS-PAGE - Recombinant Human LCE3A protein (His tag) (ab238231)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab238231.
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