Recombinant Human LCN8 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LCN8 also known as Lipocalin-8 is part of the lipocalin family. It plays role mechanically in small molecule transport and storage. This protein has a molecular mass around 20 kDa. Researchers observe its expression in various tissues with significant presence in the kidney and liver. LCN8 is also known to bind and transport various small hydrophobic molecules.

Biological function summary

This protein contributes to molecule transport and cellular homeostasis. LCN8 is known to form part of a larger complex with other lipocalin family members which lets it efficiently bind and release ligands based on the cell's needs. Its activity impacts cellular metabolism by influencing the distribution of essential biomarkers and metabolites.

Pathways

LCN8 plays a significant role in lipid metabolism and signal transduction. In the lipid metabolism pathway it cooperates with proteins like LCN2 to modulate the transport of fatty acids. Similarly in signal transduction its activity can affect pathways involving lipophilic hormone signaling providing important links and modulations for cellular communication.

LCN8 has associations with metabolic disorders including obesity and diabetes. Researchers have observed altered levels of LCN8 in patients with obesity suggesting it might influence fat storage and insulin sensitivity. In diabetes its relationship with inflammation and metabolic regulation has implications for disease progression. LCN2 is another protein implicated in these disorders sharing some overlapping functions and pathways with LCN8.