Recombinant Human LDLRAD1 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LDLRAD1 also known as Low-Density Lipoprotein Receptor Class A Domain-containing protein 1 serves key mechanical functions in cellular processes. This protein weighs approximately 54 kDa and is mainly expressed in tissues such as the liver and kidney playing roles in various cellular environments. The LDLRAD1 protein contains motifs like the low-density lipoprotein receptor class A repeats which suggest its involvement in receptor-mediated processes.

Biological function summary

This receptor is involved in cellular signaling and transport mechanisms. LDLRAD1 contributes to lipid metabolism and is part of cell surface receptor complexes. Its presence on cell membranes indicates roles in capturing and internalizing molecules from extracellular spaces. Through its domain structure LDLRAD1 assists in the modulation of signal transduction pathways that are critical for maintaining cellular health.

Pathways

LDLRAD1 integrates within lipid metabolism pathways and is associated with the regulation of cholesterol homeostasis. LDLRAD1 interacts with components such as PCSK9 which also influences cholesterol metabolism by modulating LDL receptor degradation. This interaction situates LDLRAD1 in regulatory networks that govern lipid levels in the bloodstream and affect broader metabolic functions.

LDLRAD1's connection to hypercholesterolemia and related cardiovascular conditions is significant. This protein's interaction with PCSK9 is particularly important as alterations in this pathway can lead to increased cholesterol levels contributing to atherosclerotic disease. Understanding LDLRAD1's function could offer insights into therapeutic targets for managing these lipid disorders enhancing strategies to mitigate cardiovascular risk.