Recombinant Human LDLRAD3 protein (GST tag N-Terminus)
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Recombinant Human LDLRAD3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
LRAD3, LDLRAD3, Low-density lipoprotein receptor class A domain-containing protein 3, LDLR class A domain-containing protein 3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human LDLRAD3 protein (GST tag N-Terminus) (AB165502)
ab165502 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The LDLRAD3 protein interacts with cellular processes that manage cholesterol uptake and homeostasis. It does not function as a single unit but may integrate into larger protein complexes to enhance its efficiency. Researchers suggest that LDLRAD3’s function in lipid metabolism and transport is significant particularly in the central nervous system. The collaboration of LDLRAD3 with other receptor proteins assists in regulating these activities and maintaining cellular metabolism.
Pathways
The action of the protein interfaces with lipid metabolism and signal transduction pathways. LDLRAD3 plays a role in the low-density lipoprotein receptor pathway participating in lipid uptake and signaling tied to metabolic regulation. This protein engages with the LDL receptor family connecting with proteins like ApoE which have established roles in lipid transport and cardiovascular health. LDLRAD3’s integration into these pathways highlights its physiological relevance.
Specifications
Form
Liquid
General info
Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed : 26854353).. (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
Sequence similarities
Belongs to the LDLR family.
Target data
Product promise
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