Recombinant Human LDLRAD3 protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M W L L G P L C L L L S S A A E S Q L L P G N N F T N E C N I P G N F M C S N G R C I P G A W Q C D G L P D C F D K S D E K E C P K A K S K C G P T F F P C A S G I H C I I G R F R C N G F E D C P D G S D E E N C T A N P L L C S T A R Y H C K N G L C I D K S F I C D G Q N N C Q D N S D E E S C E S S Q E P G S G Q V F V T S E N Q L V Y Y P S I T Y A I I G S S V I F V L V V A L L A L V L H H Q R K R N N L M T L P V H R L Q H P V L L S R L V V L D H P H H C N V T Y N V N N G I Q Y V A S Q A E Q N A S E V G S P P S Y S E A L L D Q R P A W Y D L P P P P Y S S D T E S L N Q A D L P P Y R S R S G S A N S A S S Q A A S S L L S V E D T S H S P G Q P G P Q E G T A E P R D S E P S Q G T E E V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
Alternative names
LRAD3, LDLRAD3, Low-density lipoprotein receptor class A domain-containing protein 3, LDLR class A domain-containing protein 3
Recommended products
Recombinant Human LDLRAD3 protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q86YD5-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M W L L G P L C L L L S S A A E S Q L L P G N N F T N E C N I P G N F M C S N G R C I P G A W Q C D G L P D C F D K S D E K E C P K A K S K C G P T F F P C A S G I H C I I G R F R C N G F E D C P D G S D E E N C T A N P L L C S T A R Y H C K N G L C I D K S F I C D G Q N N C Q D N S D E E S C E S S Q E P G S G Q V F V T S E N Q L V Y Y P S I T Y A I I G S S V I F V L V V A L L A L V L H H Q R K R N N L M T L P V H R L Q H P V L L S R L V V L D H P H H C N V T Y N V N N G I Q Y V A S Q A E Q N A S E V G S P P S Y S E A L L D Q R P A W Y D L P P P P Y S S D T E S L N Q A D L P P Y R S R S G S A N S A S S Q A A S S L L S V E D T S H S P G Q P G P Q E G T A E P R D S E P S Q G T E E V
- Accession
- Q86YD5
- Protein length
- Full Length
- Amino acids
- 1 to 345
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353).
- Sequence similarities
Belongs to the LDLR family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LDLRAD3 also known as Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 performs essential roles on a mechanical level. This protein has an approximate molecular mass of 90 kDa and is ubiquitously expressed on the cell surface of various tissues with high presence in the brain. Its structural domains facilitate interactions with extracellular molecules suggesting its involvement in transmembrane signaling. The understanding of LDLRAD3's roles benefits from studying its distribution in different cells and tissues.
- Biological function summary
The LDLRAD3 protein interacts with cellular processes that manage cholesterol uptake and homeostasis. It does not function as a single unit but may integrate into larger protein complexes to enhance its efficiency. Researchers suggest that LDLRAD3’s function in lipid metabolism and transport is significant particularly in the central nervous system. The collaboration of LDLRAD3 with other receptor proteins assists in regulating these activities and maintaining cellular metabolism.
- Pathways
The action of the protein interfaces with lipid metabolism and signal transduction pathways. LDLRAD3 plays a role in the low-density lipoprotein receptor pathway participating in lipid uptake and signaling tied to metabolic regulation. This protein engages with the LDL receptor family connecting with proteins like ApoE which have established roles in lipid transport and cardiovascular health. LDLRAD3’s integration into these pathways highlights its physiological relevance.
- Associated diseases and disorders
The involvement of LDLRAD3 links to neurological conditions and cardiovascular diseases. In Alzheimer's disease LDLRAD3 shows associations due to its interaction with ApoE an important protein involved in the disease's progression. Additionally this protein may play a part in hypercholesterolemia where LDLRAD3-mediated pathways affect cholesterol levels in the blood. These associations highlight the importance of LDLRAD3 as a research target for therapy development.
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1 product image
SDS-PAGE - Recombinant Human LDLRAD3 protein (ab165502)
ab165502 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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