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AB165502

Recombinant Human LDLRAD3 protein (GST tag N-Terminus)

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Recombinant Human LDLRAD3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 345 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

LRAD3, LDLRAD3, Low-density lipoprotein receptor class A domain-containing protein 3, LDLR class A domain-containing protein 3

1 Images
SDS-PAGE - Recombinant Human LDLRAD3 protein (GST tag N-Terminus) (AB165502)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LDLRAD3 protein (GST tag N-Terminus) (AB165502)

ab165502 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86YD5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86YD5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LDLRAD3 also known as Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 performs essential roles on a mechanical level. This protein has an approximate molecular mass of 90 kDa and is ubiquitously expressed on the cell surface of various tissues with high presence in the brain. Its structural domains facilitate interactions with extracellular molecules suggesting its involvement in transmembrane signaling. The understanding of LDLRAD3's roles benefits from studying its distribution in different cells and tissues.
Biological function summary

The LDLRAD3 protein interacts with cellular processes that manage cholesterol uptake and homeostasis. It does not function as a single unit but may integrate into larger protein complexes to enhance its efficiency. Researchers suggest that LDLRAD3’s function in lipid metabolism and transport is significant particularly in the central nervous system. The collaboration of LDLRAD3 with other receptor proteins assists in regulating these activities and maintaining cellular metabolism.

Pathways

The action of the protein interfaces with lipid metabolism and signal transduction pathways. LDLRAD3 plays a role in the low-density lipoprotein receptor pathway participating in lipid uptake and signaling tied to metabolic regulation. This protein engages with the LDL receptor family connecting with proteins like ApoE which have established roles in lipid transport and cardiovascular health. LDLRAD3’s integration into these pathways highlights its physiological relevance.

The involvement of LDLRAD3 links to neurological conditions and cardiovascular diseases. In Alzheimer's disease LDLRAD3 shows associations due to its interaction with ApoE an important protein involved in the disease's progression. Additionally this protein may play a part in hypercholesterolemia where LDLRAD3-mediated pathways affect cholesterol levels in the blood. These associations highlight the importance of LDLRAD3 as a research target for therapy development.

Specifications

Form

Liquid

General info

Function

May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed : 26854353).. (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.

Sequence similarities

Belongs to the LDLR family.

Product protocols

Target data

May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed : 26854353).. (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
See full target information LDLRAD3

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