Recombinant Human LECT2 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The target 'LECT2' also known as leukocyte cell-derived chemotaxin 2 is a 16 kDa protein. It plays a role in immune response and signaling by acting as a chemotactic factor for neutrophils. LECT2 is a secreted protein primarily expressed in the liver and found in circulation in the bloodstream. It has been associated with acute-phase response and inflammation.

Biological function summary

LECT2 contributes to tissue regeneration liver function and modulation of immune responses. It is not known to be part of a larger protein complex but interacts with multiple receptor types on cell surfaces. LECT2 can inhibit mitogen-activated protein kinase (MAPK) pathway by binding to specific receptors affecting cell proliferation and survival. It also plays a role in metabolic processes.

Pathways

The LECT2 protein influences the MAPK and JNK pathways impacting cellular stress responses and inflammatory signaling. Its interactions with other proteins involve MAPK family members like p38 and ERK. These pathways regulate various cellular activities such as proliferation apoptosis and cytokine production positioning LECT2 as a modulator of cellular signaling networks.

Associated diseases and disorders

LECT2 has strong connections to liver-related conditions such as fatty liver disease and liver fibrosis. It also associates with conditions like amyloid A kidney amyloidosis. In these diseases LECT2 interacts with inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which play roles in inflammation and fibrosis. These interactions can alter disease outcomes and affect therapeutic strategies targeting these inflammatory pathways.