Recombinant Human LEFTY2 protein (His tag) is a Human Full Length protein, in the 78 to 366 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
H H H H H H F S Q S F R E V A G R F L A S E A S T H L L V F G M E Q R L P P N S E L V Q A V L R L F Q E P V P K A A L H R H G R L S P R S A Q A R V T V E W L R V R D D G S N R T S L I D S R L V S V H E S G W K A F D V T E A V N F W Q Q L S R P R Q P L L L Q V S V Q R E H L G P L A S G A H K L V R F A S Q G A P A G L G E P Q L E L H T L D L R D Y G A Q G D C D P E A P M T E G T R C C R Q E M Y I D L Q G M K W A K N W V L E P P G F L A Y E C V G T C Q Q P P E A L A F N W P F L G P R Q C I A S E T A S L P M I V S I K E G G R T R P Q V V S L P N M R V Q K C S C A S D G A L V P R R L Q P
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
EBAF, LEFTA, LEFTYA, TGFB4, PSEC0024, LEFTY2, Left-right determination factor 2, Endometrial bleeding-associated factor, Left-right determination factor A, Protein lefty-2, Protein lefty-A, Transforming growth factor beta-4, TGF-beta-4
Recombinant Human LEFTY2 protein (His tag) is a Human Full Length protein, in the 78 to 366 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
pH: 7.4
Constituents: PBS
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Belongs to the TGF-beta family.
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
LEFTY2 also known as Left-Right Determination Factor 2 is a member of the transforming growth factor beta (TGF-β) superfamily. This protein has a molecular mass of approximately 38 kDa. LEFTY2 is expressed mainly in visceral endoderm and left side mesoderm tissues. The gene encoding LEFTY2 is found within the human chromosome 1. This protein plays a mechanical role in the regulation of cellular signaling and developmental processes.
LEFTY2 functions as an important regulator in ensuring proper left-right asymmetry during embryonic development. It is a monomeric protein that is not part of a larger complex. LEFTY2 contributes to the modulation of Nodal signaling inhibiting excessive activity that can disrupt normal development. This modulation ensures the establishment of asymmetric organ positioning and plays an important role in maintaining developmental balance in the body.
LEFTY2 integrates into the Nodal signaling pathway and the Activin signaling pathway. The interaction with Nodal proteins narrows down Nodal signaling ensuring the accurate development of the left-right axis. LEFTY2 also relates functionally and antagonistically to other proteins like Nodal and Activin A balancing their signaling actions to regulate developmental processes.
LEFTY2 has a connection with asymmetry-related conditions such as situs inversus where organ placement within the body is mirrored from normal positions. Additionally research links irregular LEFTY2 expression to some cancer types including ovarian cancer. Through these disorders LEFTY2 interacts with proteins like Nodal which plays a role in cancer cell proliferation by influencing the signaling pathways that govern cellular growth and differentiation.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com