Recombinant Human LETMD1/HCCR-1 protein is a Human Fragment protein, in the 183 to 330 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013).
Alternative names
LETM1 domain-containing protein 1, Cervical cancer 1 proto-oncogene protein p40, Cervical cancer proto-oncogene 2 protein, HCCR-1, HCRR-2, LETMD1
Recommended products
Recombinant Human LETMD1/HCCR-1 protein is a Human Fragment protein, in the 183 to 330 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q6P1Q0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
Constituents: 2.68% PBS
Sequence info
Amino acid sequence
- Protein length
- Fragment
- Amino acids
- 183 to 330
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013).
- Subcellular localisation
- Mitochondrion outer membrane
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as LETMD1
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LETMD1 also known as HCCR-1 functions mechanically as a mitochondrial protein that plays a role in regulating mitochondrial activity and cellular apoptosis. With a mass of approximately 60 kDa LETMD1/HCCR-1 is expressed in various tissues including the liver kidney and lung. This protein has been identified to participate in the mitochondrial pathways and contribute to cellular homeostasis and energy metabolism.
- Biological function summary
LETMD1/HCCR-1 affects cellular processes like cell growth and death by impacting the mitochondrial function critical to these processes. Although not specifically a component of a known complex this protein influences important cellular dynamics. Its role in the regulation of apoptosis links LETMD1/HCCR-1 to cellular survival implying its importance in balancing cell proliferation and death under physiological conditions.
- Pathways
LETMD1/HCCR-1 is associated closely with apoptosis and mitochondrial pathways. The protein regulates apoptosis interacting with members of the Bcl-2 family of proteins which are important in apoptosis regulation. LETMD1/HCCR-1's connection to mitochondrial dynamics also overlaps with pathways involving mitochondrial fusion and fission highlighting its integrative role in maintaining cellular energy balance and function.
- Associated diseases and disorders
LETMD1/HCCR-1 links to cancer and neurodegenerative disorders. Overexpression of LETMD1/HCCR-1 has been noted in various cancers where it may promote tumor cell survival through inhibition of apoptosis. Neurodegenerative diseases such as Alzheimer's disease also show LETMD1/HCCR-1 involvement possibly through its interaction with proteins like p53 which is significant in cell cycle regulation and apoptosis. Understanding LETMD1/HCCR-1's interaction with these proteins aids in exploring therapeutic targets for these conditions.
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1 product image
SDS-PAGE - Recombinant Human LETMD1/HCCR-1 protein (ab79566)
ab79566 on 15% SDS PAGE gel, Coomassie blue staining.
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