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AB271590

Recombinant Human LILRA1 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus)

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Recombinant Human LILRA1 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 17 to 461 aa range, expressed in HEK 293 cells, with >90%.

View Alternative Names

CD85i, LIR6, LILRA1, Leukocyte immunoglobulin-like receptor subfamily A member 1, CD85 antigen-like family member I, Leukocyte immunoglobulin-like receptor 6, LIR-6

1 Images
SDS-PAGE - Recombinant Human LILRA1 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) (AB271590)
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Supplier Data

SDS-PAGE - Recombinant Human LILRA1 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) (AB271590)

SDS-PAGE analysis of ab271590.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus His tag C-Terminus

Biologically active

No

Conjugation

Biotin

Excitation/Emission
Accession

O75019

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Product details

Enzymatically biotin-labeled using Avi-tag™ technology.

Biotinylation is confirmed to be ≥90%.

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Sequence info

[{"sequence":"PRTHVQAGTLPKPTLWAEPGSVITQGSPVTLWCQGILETQEYRLYREKKTAPWITRIPQEIVKKGQFPIPSITWEHTGRYRCFYGSHTAGWSEPSDPLELVVTGAYIKPTLSALPSPVVTSGGNVTLHCVSQVAFGSFILCKEGEDEHPQCLNSQPRTHGWSRAIFSVGPVSPSRRWSYRCYAYDSNSPHVWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPGESLTLQCVSDVSYDRFVLYKEGERDFLQLPGPQPQAGLSQANFTLGPVSRSYGGQYRCSGAYNLSSEWSAPSDPLDILIAGQFRGRPFISVHPGPTVASGENVTLLCQSWGPFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHSGTYRCYGSLSSNPYLLSHPSDSLELMVSGAAETLSPPQNKSDSKAGAANTLSPSQNKTASHPQDYTVEN","proteinLength":"Fragment","predictedMolecularWeight":"51 kDa","actualMolecularWeight":null,"aminoAcidEnd":461,"aminoAcidStart":17,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O75019","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle|Store in the dark
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The LILRA1 protein also known as Leukocyte Immunoglobulin-like Receptor A1 is a member of the leukocyte immunoglobulin-like receptor family. It has a mass of approximately 55 kDa. This protein is widely expressed on various immune cells including monocytes macrophages and some subsets of dendritic cells and B lymphocytes. LILRA1 plays a significant role in modulating immune responses by binding to its ligands which leads to the activation or inhibition of different immune cell functions.
Biological function summary

LILRA1 interacts with the immune system by modulating cell signaling and immune response. It often forms part of a signaling complex that can impact cell activation and cytokine production. This protein is responsible for balancing immune reactions which is important for preventing overactive immune responses. LILRA1 participates in maintaining homeostasis within the immune system by regulating the activity of immune cells based on the presence of pathogens and other antigens.

Pathways

LILRA1 is involved in the immune response pathway and the Fc receptor signaling pathway. It works closely with other LILR family members and shares some functional redundancy with proteins like LILRB1. LILRA1 plays an important role in the modulation of signaling cascades that ultimately influence immune cell behavior including phagocytosis and antigen presentation essential processes for the effective functioning of the adaptive immune response.

LILRA1 has been associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. This association arises due to its involvement in immune regulation and potential disruption in autoimmune states. LILRA1's interaction with proteins such as LILRB1 highlights its role in these disorders where it may influence disease progression by altering immune response thresholds. Understanding LILRA1’s functions further aids in exploring therapeutic interventions targeting these conditions.
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Specifications

Form

Liquid

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General info

Function

May act as receptor for class I MHC antigens.

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Product protocols

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Target data

May act as receptor for class I MHC antigens.
See full target information LILRA1
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Product promise

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