Recombinant Human LIN7C protein
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Recombinant Human LIN7C protein is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
MALS3, VELI3, LIN7C, Protein lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, Vertebrate lin-7 homolog 3, MALS-3, Veli-3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human LIN7C protein (AB137173)
15% SDS-PAGE analysis of ab137173 (3μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LIN7C contributes significantly to cellular signaling and organization. It operates as part of a multiprotein complex alongside DLG1 and CASK interacting with several other proteins to facilitate cell adhesion and synaptic transmission. This assembly orchestrates the anchoring of membrane proteins influencing the spatial distribution of signaling receptors. LIN7C's role ensures that proteins reach and maintain their proper membrane location important for successful synaptic and epithelial cell functioning.
Pathways
LIN7C is actively involved in the PI3K/AKT pathway critical for cell survival and proliferation. LIN7C assists in stabilizing interactions with signaling molecules like GRIN2B contributing to synaptic plasticity and memory formation. Additionally LIN7C engages with the Wnt signaling pathway which influences cell development and differentiation through interactions with proteins such as LRP6. This interaction emphasizes LIN7C's importance in processes that guide cellular growth and differentiation.
Specifications
Form
Liquid
Additional notes
ab137173 was purified using conventional chromatography techniques.
General info
Function
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Sequence similarities
Belongs to the lin-7 family.
Target data
Complementary Products
Product promise
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