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AB165693

Recombinant Human LINGO2 protein (GST tag N-Terminus)

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Recombinant Human LINGO2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 606 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

LERN3, LRRN6C, UNQ9234/PRO31993, LINGO2, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2, Leucine-rich repeat neuronal protein 3, Leucine-rich repeat neuronal protein 6C

1 Images
SDS-PAGE - Recombinant Human LINGO2 protein (GST tag N-Terminus) (AB165693)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LINGO2 protein (GST tag N-Terminus) (AB165693)

ab165693 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q7L985

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human Zinc finger protein 276 (GST tag N-Terminus) (AB164919)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":606,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q7L985","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LINGO2 also known as LRRN6C is a protein with a molecular mass of approximately 70 kDa. It belongs to the leucine-rich repeat (LRR) family which is involved in protein-protein interactions. LINGO2 is expressed mainly in the central nervous system particularly in neurons where it plays a role in cellular signaling. The protein structure allows it to engage in interactions important for cellular communication.
Biological function summary

LINGO2 participates in nerve growth modulation and influences the development and repair of neural networks. It often partners with other proteins to form signaling complexes. These complexes affect processes like myelination the formation of insulating coverings around nerves which are essential for efficient nerve impulse transmission. By modulating signaling LINGO2 impacts neural plasticity and regeneration.

Pathways

LINGO2 integrates within neuronal signaling pathways such as the RhoA and the Notch pathway. It interacts with other proteins including LINGO1 influencing the RhoA pathway which plays a role in cytoskeletal dynamics and affects axonal growth cones. These pathways are critical for maintaining neuronal architecture and in response to injury or during development.

LINGO2 has associations with neurological conditions like Parkinson's disease and Multiple Sclerosis. The involvement of LINGO2 in these disorders relates to its regulatory role in neuronal repair and myelination processes. In the context of Parkinson's disease aberrant LINGO2 activity may affect dopamine signaling pathways similar to the influence of LINGO1. This shared pathway involvement suggests that both proteins could become targets for therapeutic strategies aimed at modulating neural function and repair.
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Specifications

Form

Liquid

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General info

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Product protocols

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Target data

See full target information LINGO2
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