Recombinant Human Liver Arginase protein is a Human Full Length protein, in the 1 to 322 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
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- Bioorganic & medicinal chemistry 26:3939-39462018Rational design of novel irreversible inhibitors for human arginase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuefeng Guo et. al.PubMed 29914772
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M S A K S R T I G I I G A P F S K G Q P R G G V E E G P T V L R K A G L L E K L K E Q E C D V K D Y G D L P F A D I P N D S P F Q I V K N P R S V G K A S E Q L A G K V A E V K K N G R I S L V L G G D H S L A I G S I S G H A R V H P D L G V I W V D A H T D I N T P L T T T S G N L H G Q P V S F L L K E L K G K I P D V P G F S W V T P C I S A K D I V Y I G L R D V D P G E H Y I L K T L G I K Y F S M T E V D R L G I G K V M E E T L S Y L L G R K K R P I H L S F D V D G L D P S F T P A T G T P V V G G L T Y R E G L Y I T E E I Y K T G L L S G L D I M E V N P S L G K T P E E V T R T V N T A V A I T L A C F G L A R E G N H K P I D Y L N P P K L E H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Alternative names
Arginase-1, Liver-type arginase, Type I arginase, ARG1
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Recombinant Human Liver Arginase protein is a Human Full Length protein, in the 1 to 322 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P05089-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M S A K S R T I G I I G A P F S K G Q P R G G V E E G P T V L R K A G L L E K L K E Q E C D V K D Y G D L P F A D I P N D S P F Q I V K N P R S V G K A S E Q L A G K V A E V K K N G R I S L V L G G D H S L A I G S I S G H A R V H P D L G V I W V D A H T D I N T P L T T T S G N L H G Q P V S F L L K E L K G K I P D V P G F S W V T P C I S A K D I V Y I G L R D V D P G E H Y I L K T L G I K Y F S M T E V D R L G I G K V M E E T L S Y L L G R K K R P I H L S F D V D G L D P S F T P A T G T P V V G G L T Y R E G L Y I T E E I Y K T G L L S G L D I M E V N P S L G K T P E E V T R T V N T A V A I T L A C F G L A R E G N H K P I D Y L N P P K L E H H H H H H
- Accession
- P05089
- Protein length
- Full Length
- Predicted molecular weight
- 35.8 kDa
- Amino acids
- 1 to 322
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
Purified by using conventional chromatography techniques
General info
- Function
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.
- Sequence similarities
Belongs to the arginase family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
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1 product image
SDS-PAGE - Recombinant Human Liver Arginase protein (ab95487)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
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