Recombinant Human LMO1 protein (denatured) is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M M V L D K E D G V P M L S V Q P K G K Q K G C A G C N R K I K D R Y L L K A L D K Y W H E D C L K C A C C D C R L G E V G S T L Y T K A N L I L C R R D Y L R L F G T T G N C A A C S K L I P A F E M V M R A R D N V Y H L D C F A C Q L C N Q R F C V G D K F F L K N N M I L C Q M D Y E E G Q L N G T F E S Q V Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Alternative names
RBTN1, RHOM1, TTG1, LMO1, Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, T-cell translocation protein 1, LMO-1
Recommended products
Recombinant Human LMO1 protein (denatured) is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P25800-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M M V L D K E D G V P M L S V Q P K G K Q K G C A G C N R K I K D R Y L L K A L D K Y W H E D C L K C A C C D C R L G E V G S T L Y T K A N L I L C R R D Y L R L F G T T G N C A A C S K L I P A F E M V M R A R D N V Y H L D C F A C Q L C N Q R F C V G D K F F L K N N M I L C Q M D Y E E G Q L N G T F E S Q V Q
- Accession
- P25800
- Protein length
- Full Length
- Predicted molecular weight
- 20.2 kDa
- Amino acids
- 1 to 156
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LMO1 also known as LIM domain only protein 1 is a small nuclear protein involved in gene transcription regulation. It consists of two LIM domains and has a molecular mass of approximately 21 kDa. LMO1 does not contain any DNA-binding domains implying that it relies on other factors for DNA interaction. This protein is mainly expressed in the nervous system the immune system and various cancer cell lines. Its expression is tightly regulated during development suggesting its role in cell differentiation and proliferation processes.
- Biological function summary
Proteins like LMO1 function as transcriptional regulators by forming complexes with other nuclear proteins. LMO1 acts as a scaffold facilitating the assembly of multi-protein complexes that modulate gene expression. Often it connects with GATA-binding transcription factors and other LIM domain proteins influencing transcriptional outcomes. In particular LMO1 impacts hematopoiesis by affecting the development of blood cells highlighting its importance in maintaining proper immune function.
- Pathways
Multiple proteins like LMO1 connect to key cellular pathways influencing cell fate decisions and growth. LMO1 is involved in the NOTCH signaling pathway a critical regulator of cell differentiation and proliferation. It collaborates with proteins such as TAL1 and GATA proteins affecting how signals within this pathway are interpreted and leading to changes in gene expression. Another pathway involving LMO1 is the WNT signaling pathway which governs various aspects of development and cellular responses.
- Associated diseases and disorders
Proteins like LMO1 have been linked to neuroblastoma a common cancer in children and T-cell acute lymphoblastic leukemia (T-ALL) a type of blood cancer. In neuroblastoma LMO1 alterations may facilitate unchecked cell proliferation and survival often in conjunction with MYCN amplification. In T-ALL LMO1 interacts with TAL1 a well-known oncogenic transcription factor contributing to leukemogenesis by deregulating normal blood cell development processes.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human LMO1 protein (denatured) (ab156325)
15% SDS-PAGE analysis of ab156325 (3μg).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com