Recombinant Human LMO1 protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LMO1 also known as LIM domain only protein 1 is a small nuclear protein involved in gene transcription regulation. It consists of two LIM domains and has a molecular mass of approximately 21 kDa. LMO1 does not contain any DNA-binding domains implying that it relies on other factors for DNA interaction. This protein is mainly expressed in the nervous system the immune system and various cancer cell lines. Its expression is tightly regulated during development suggesting its role in cell differentiation and proliferation processes.

Biological function summary

Proteins like LMO1 function as transcriptional regulators by forming complexes with other nuclear proteins. LMO1 acts as a scaffold facilitating the assembly of multi-protein complexes that modulate gene expression. Often it connects with GATA-binding transcription factors and other LIM domain proteins influencing transcriptional outcomes. In particular LMO1 impacts hematopoiesis by affecting the development of blood cells highlighting its importance in maintaining proper immune function.

Pathways

Multiple proteins like LMO1 connect to key cellular pathways influencing cell fate decisions and growth. LMO1 is involved in the NOTCH signaling pathway a critical regulator of cell differentiation and proliferation. It collaborates with proteins such as TAL1 and GATA proteins affecting how signals within this pathway are interpreted and leading to changes in gene expression. Another pathway involving LMO1 is the WNT signaling pathway which governs various aspects of development and cellular responses.

Proteins like LMO1 have been linked to neuroblastoma a common cancer in children and T-cell acute lymphoblastic leukemia (T-ALL) a type of blood cancer. In neuroblastoma LMO1 alterations may facilitate unchecked cell proliferation and survival often in conjunction with MYCN amplification. In T-ALL LMO1 interacts with TAL1 a well-known oncogenic transcription factor contributing to leukemogenesis by deregulating normal blood cell development processes.