Recombinant Human LMO2 protein is a Human Full Length protein, in the 1 to 158 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M S S A I E R K S L D P S E E P V D E V L Q I P P S L L T C G G C Q Q N I G D R Y F L K A I D Q Y W H E D C L S C D L C G C R L G E V G R R L Y Y K L G R K L C R R D Y L R P F G Q D G L C A S C D K R I R A Y E M T M R V K D K V Y H L E C F K C A A C Q K H F C V G D R Y L L I N S D I V C E Q D I Y E W T K I N G M I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Alternative names
RBTN2, RBTNL1, RHOM2, TTG2, LMO2, Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2, LMO-2
Recommended products
Recombinant Human LMO2 protein is a Human Full Length protein, in the 1 to 158 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P25791-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M S S A I E R K S L D P S E E P V D E V L Q I P P S L L T C G G C Q Q N I G D R Y F L K A I D Q Y W H E D C L S C D L C G C R L G E V G R R L Y Y K L G R K L C R R D Y L R P F G Q D G L C A S C D K R I R A Y E M T M R V K D K V Y H L E C F K C A A C Q K H F C V G D R Y L L I N S D I V C E Q D I Y E W T K I N G M I
- Accession
- P25791
- Protein length
- Full Length
- Predicted molecular weight
- 43.12 kDa
- Amino acids
- 1 to 158
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LMO2 also known as LIM Domain Only 2 is a transcription factor with a molecular weight of approximately 24 kDa. It contains two LIM domains which enable protein-protein interactions. LMO2 expression is mostly found in hematopoietic tissues and the vascular endothelium. This protein does not directly bind DNA but forms complexes with other proteins to exert its regulatory roles.
- Biological function summary
This transcription factor is important in hematopoiesis and angiogenesis. LMO2 forms multiprotein complexes that include TAL1 GATA1 and E47 which are necessary for the transcriptional activation of genes involved in blood cell differentiation and formation. Its role in angiogenesis involves participating in the transcriptional regulation of genes essential for blood vessel formation.
- Pathways
LMO2 plays a significant role in the development of the hematopoietic system and vascular network. It is part of the TAL1-LMO2-LDB1 transcriptional complex within the hematopoietic transcriptional network which includes other key proteins like GATA1 and E47. These pathways ensure proper development and differentiation of various blood cell lineages and endothelial cells.
- Associated diseases and disorders
LMO2 has a known association with T-cell acute lymphoblastic leukemia (T-ALL) and some other hematological malignancies. Abnormal expression of LMO2 can lead to oncogenic transformation in hematopoietic cells. Within these disease contexts LMO2 interacts with proteins like TAL1 and LDB1 contributing to leukemogenic processes. Understanding its role helps in the development of therapeutic strategies targeting these pathways.
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1 product image
SDS-PAGE - Recombinant Human LMO2 protein (ab152503)
12.5% SDS-PAGE analysis of ab152503 stained with Coomassie Blue.
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Product protocols
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