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AB204145

Recombinant Human LMTK2 protein

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Recombinant Human LMTK2 protein is a Human Fragment protein, in the 66 to 583 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE.

View Alternative Names

AATYK2, BREK, KIAA1079, KPI2, LMR2, LMTK2, Serine/threonine-protein kinase LMTK2, Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, CDK5/p35-regulated kinase, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2, Serine/threonine-protein kinase KPI-2, hBREK, CPRK

1 Images
SDS-PAGE - Recombinant Human LMTK2 protein (AB204145)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human LMTK2 protein (AB204145)

SDS-PAGE analysis of ab204145. MW 96 KDa.

Key facts

Purity

>80% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8IWU2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.307% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"VSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTG","proteinLength":"Fragment","predictedMolecularWeight":"96 kDa","actualMolecularWeight":null,"aminoAcidEnd":583,"aminoAcidStart":66,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q8IWU2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The LMTK2 protein also known as Lemur Tyrosine Kinase 2 is a serine/threonine kinase with an approximated mass of 150 kDa. It plays an important role in protein phosphorylation influencing various cellular processes. LMTK2 is expressed in multiple tissues notably in the brain and testis. Its kinase activity impacts neurodevelopment and spermatogenesis reflecting its significant presence in these areas.
Biological function summary

LMTK2 influences neuron maintenance and signaling. It is not known to be part of any large protein complex but interacts closely with important cellular proteins. LMTK2 has a regulatory effect on axonal outgrowth and synaptic vesicle transport which are essential for neuron function. Moreover it interacts with other kinases and phosphatases impacting cellular signal transduction pathways.

Pathways

LMTK2 has important roles in the Wnt and MAPK signaling pathways. Within the Wnt pathway LMTK2 modulates cellular growth and differentiation by interacting with proteins like beta-catenin. In the MAPK pathway its influence on kinases helps control cell proliferation and stress responses. The interactions of LMTK2 with these signaling pathways highlight its influence on cell fate decisions and adaptive responses.

LMTK2 associates with neurodegenerative diseases and cancer. Its dysfunction has been linked to Alzheimer's disease where aberrant signaling affects neuronal health. LMTK2 potentially interacts with tau protein impacting tau pathology. In cancer altered LMTK2 expression associates with disrupted cellular growth signaling suggesting a role in tumor progression. Understanding these connections offers insights for therapeutic innovations.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Phosphorylates PPP1C, phosphorylase b and CFTR.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Post-translational modifications

Autophosphorylated. Phosphorylated (By similarity).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Phosphorylates PPP1C, phosphorylase b and CFTR.
See full target information LMTK2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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