Recombinant Human LOC134147/CMBL protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LOC134147 often called CMBL (carboxymethylenebutenolidase-like protein) functions as an enzyme with a pivotal role in detoxification processes. This protein weighs approximately 30 kDa and exhibits carboxymethylenebutenolidase activity catalyzing the hydrolysis of carboxymethylenebutenolide to produce carboxymethylenebutenolide lactone and an alcohol. Expression of CMBL occurs in various tissues but it is highly present in the liver indicating its connection to metabolic processes in detoxification and drug metabolism.

Biological function summary

CMBL facilitates the efficient breakdown of certain xenobiotics and endogenous compounds contributing to cellular detoxification mechanisms. As a standalone enzyme it does not participate in large protein complexes but its activity assists the liver in processing numerous therapeutic drugs and harmful compounds. The liver's expression of CMBL highlights its role in maintaining metabolic balance and cellular homeostasis against various chemical exposures.

Pathways

The function of CMBL fits into the broader context of metabolic and detoxification pathways specifically xenobiotic metabolism and retinoic acid biosynthesis. CMBL is actively involved in the hydrolysis step working alongside enzymes like aldehyde dehydrogenase in detoxification processes. This association enables efficient processing and neutralization of exogenous substances aiding in the maintenance of chemical homeostasis within the human body.

Alterations in CMBL activity can affect disease states notably impacting drug efficacy and safety. Anomalous function of CMBL is suspected to be connected with variations in drug response including drug-induced liver injury. Through drug metabolic pathways it indirectly interacts with proteins like cytochrome P450 which also modulate drug metabolism and detoxification influencing therapeutic outcomes. Understanding CMBL's role aids in improving drug safety and personalized medicine strategies.