Recombinant Human LOXL3 protein (Tagged) is a Human Fragment protein, in the 526 to 753 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for WB.
>90% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
WB
No
E T A S D L L L H S A L V Q E T A Y I E D R P L H M L Y C A A E E N C L A S S A R S A N W P Y G H R R L L R F S S Q I H N L G R A D F R P K A G R H S W V W H E C H G H Y H S M D I F T H Y D I L T P N G T K V A E G H K A S F C L E D T E C Q E D V S K R Y E C A N F G E Q G I T V G C W D L Y R H D I D C Q W I D I T D V K P G N Y I L Q V V I N P N F E V A E S D F T N N A M K C N C K Y D G H R I W V H N C H I G D A F S E E A N R R F E R Y P G Q T S N Q I I
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).Isoform 1Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).Isoform 2Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).
LOXL, LOXL3, Lysyl oxidase homolog 3, Lysyl oxidase-like protein 3
Recombinant Human LOXL3 protein (Tagged) is a Human Fragment protein, in the 526 to 753 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for WB.
>90% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
WB
No
No
Human
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
E T A S D L L L H S A L V Q E T A Y I E D R P L H M L Y C A A E E N C L A S S A R S A N W P Y G H R R L L R F S S Q I H N L G R A D F R P K A G R H S W V W H E C H G H Y H S M D I F T H Y D I L T P N G T K V A E G H K A S F C L E D T E C Q E D V S K R Y E C A N F G E Q G I T V G C W D L Y R H D I D C Q W I D I T D V K P G N Y I L Q V V I N P N F E V A E S D F T N N A M K C N C K Y D G H R I W V H N C H I G D A F S E E A N R R F E R Y P G Q T S N Q I I
Fragment
54 kDa
526 to 753
Recombinant
GST tag N-Terminus
Liquid
Affinity purified.
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).
Belongs to the lysyl oxidase family.
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Nucleus
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
SDS-PAGE showing ab174063
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com