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AB194037

Recombinant Human LRRC25/MAPA protein

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Recombinant Human LRRC25/MAPA protein is a Human Fragment protein, in the 21 to 165 aa range, expressed in HEK 293 cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

MAPA, UNQ6169/PRO20174, LRRC25, Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 0.1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q8N386

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride

storage-buffer

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Complementary Products

Primary Antibodies

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Anti-LRRC25/MAPA antibody [OTI1D9]

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Proteins & Peptides

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Proteins & Peptides

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Proteins & Peptides

AB183234

Recombinant Human HMGN3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human HMGN3 protein (His tag N-Terminus) (AB183234)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as LRRC25
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Sequence info

[{"sequence":"LEPSCTVSSADVDWNAEFSATCLNFSGLSLSLPHNQSLRASNVILLDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDGALAARCDLDLQADCNCALESWHDIRRDNCSGQKPLLCWDTTSSQHNLSAFLEVSCAPGLASATVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"16.72 kDa","actualMolecularWeight":null,"aminoAcidEnd":165,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8N386","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRC25 also known as MAPA is a protein characterized by leucine-rich repeat motifs that facilitate protein-protein interactions. This protein often acts as a receptor within cellular processes. Its molecular mass is approximately 73 kDa. You can find LRRC25 expression in various tissues with a concentration in the immune and epithelial cells reflecting its role in the immune response.
Biological function summary

The protein carries out functions connected to the innate immune system. LRRC25 is involved in modulating cellular responses to external stimuli like pathogens. It is a part of the complex responsible for the immune response working alongside Toll-like receptors. This involvement allows LRRC25 to participate actively in recognizing and responding to microbial infections suggesting its importance for immune activation.

Pathways

LRRC25 plays a role in signaling cascades such as the NF-kB pathway. Its interaction with proteins like MyD88 illustrates its role in signaling pathways leading to inflammation and immune responses. LRRC25 acts as a link between pathogen recognition and downstream transcriptional responses ensuring the proper defense mechanism of the cells.

An altered expression or malfunction of LRRC25 has links to autoimmune diseases and chronic inflammation conditions. For example studies associate LRRC25 with rheumatoid arthritis where it interacts with inflammatory cytokines through the modulation of NF-kB activity. Also researchers observe its association with systemic lupus erythematosus where it may influence the disease's progression by affecting the immune response.
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Specifications

Form

Lyophilized

Additional notes

The purity of ab194037 was determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed : 29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.

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Product protocols

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Target data

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed : 29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
See full target information LRRC25
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