Recombinant Human LRRC25/MAPA protein is a Human Fragment protein, in the 21 to 165 aa range, expressed in HEK 293, with >95% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
L E P S C T V S S A D V D W N A E F S A T C L N F S G L S L S L P H N Q S L R A S N V I L L D L S G N G L R E L P V T F F A H L Q K L E V L N V L R N P L S R V D G A L A A R C D L D L Q A D C N C A L E S W H D I R R D N C S G Q K P L L C W D T T S S Q H N L S A F L E V S C A P G L A S A T V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
MAPA, UNQ6169/PRO20174, LRRC25, Leucine-rich repeat-containing protein 25, Monocyte and plasmacytoid-activated protein
Recombinant Human LRRC25/MAPA protein is a Human Fragment protein, in the 21 to 165 aa range, expressed in HEK 293, with >95% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 7.4
Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride
The purity of ab194037 was determined by SEC-HPLC and reducing SDS-PAGE.
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
This product was previously labelled as LRRC25
LRRC25 also known as MAPA is a protein characterized by leucine-rich repeat motifs that facilitate protein-protein interactions. This protein often acts as a receptor within cellular processes. Its molecular mass is approximately 73 kDa. You can find LRRC25 expression in various tissues with a concentration in the immune and epithelial cells reflecting its role in the immune response.
The protein carries out functions connected to the innate immune system. LRRC25 is involved in modulating cellular responses to external stimuli like pathogens. It is a part of the complex responsible for the immune response working alongside Toll-like receptors. This involvement allows LRRC25 to participate actively in recognizing and responding to microbial infections suggesting its importance for immune activation.
LRRC25 plays a role in signaling cascades such as the NF-kB pathway. Its interaction with proteins like MyD88 illustrates its role in signaling pathways leading to inflammation and immune responses. LRRC25 acts as a link between pathogen recognition and downstream transcriptional responses ensuring the proper defense mechanism of the cells.
An altered expression or malfunction of LRRC25 has links to autoimmune diseases and chronic inflammation conditions. For example studies associate LRRC25 with rheumatoid arthritis where it interacts with inflammatory cytokines through the modulation of NF-kB activity. Also researchers observe its association with systemic lupus erythematosus where it may influence the disease's progression by affecting the immune response.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com