Recombinant Human LRRC59 protein (His tag N-Terminus)
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Recombinant Human LRRC59 protein (His tag N-Terminus) is a Human Fragment protein, in the 1 to 244 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
PRO1855, LRRC59, Leucine-rich repeat-containing protein 59, Ribosome-binding protein p34, p34
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human LRRC59 protein (His tag N-Terminus) (AB171695)
15% SDS-PAGE analysis of ab171695 (3 µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LRRC59 is involved in nuclear import pathways and acts as an anchor for certain proteins that need to be translocated into the nucleus. It interacts with the importin-family proteins to facilitate the transport of proteins with nuclear localization signals. LRRC59 works as a part of a larger protein complex which includes importin and nucleoporins to control transport into the nucleus. This positioning suggests that LRRC59 has an active role in regulating gene expression by controlling the nuclear entry of transcription factors and other nuclear proteins.
Pathways
LRRC59 plays a part in cellular transport and signaling pathways. It integrates into the nuclear transport pathway directly influencing gene expression by ensuring the proper nuclear import of signaling molecules. In particular it influences the well-known MAPK signaling pathway through interactions with other proteins like importin-β. These associations emphasize LRRC59’s role in maintaining cellular homeostasis and its potential impact on several signaling cascades.
Specifications
Form
Liquid
Additional notes
ab171695 is purified using conventional chromatography techniques.
General info
Function
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
Subcellular localisation
Nucleus envelope
Target data
Complementary Products
Product promise
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