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AB152058

Recombinant Human LRRTM2 protein

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Recombinant Human LRRTM2 protein is a Human Fragment protein, in the 34 to 422 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

KIAA0416, LRRN2, LRRTM2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

O43300

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"CPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"45.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":422,"aminoAcidStart":34,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O43300","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Leucine-Rich Repeat Transmembrane Neuronal Protein 2 (LRRTM2) also known as C22orf34 is a protein with a molecular weight of approximately 68 kDa. This protein plays a role in synapse formation by promoting synaptogenesis and maintaining synaptic stability. LRRTM2 is highly expressed in the central nervous system especially in the hippocampus and cortex regions of the brain. It also locates primarily at the postsynaptic membranes of excitatory synapses where it interacts with extracellular matrix components and other cell adhesion molecules.
Biological function summary

LRRTM2 is essential for modulating excitatory synaptic strength and plasticity. The protein is part of a larger complex interacting with presynaptic neurexins which are involved in synapse specification. These interactions help stabilize the synapse and influence synaptic remodeling. LRRTM2 contributes to the efficient transmission of nerve signals by regulating the recruitment of presynaptic vesicles and postsynaptic receptors shaping the communication network within the neuronal circuits.

Pathways

LRRTM2 is a component of synaptic transmission and plasticity pathways. It plays a role in the synaptogenesis pathway involving neurexins and neuroligins which are important for synapse development and maturation. The balance and interaction between LRRTM family members like LRRTM1 and LRRTM3 influence synaptic connections and can modulate neural circuit assembly. LRRTM2's function within these pathways impacts the strength and specificity of synaptic interactions essential for learning and memory processes.

LRRTM2 has associations with psychiatric conditions such as schizophrenia and autism spectrum disorder. LRRTM2's disruption can impair synaptic plasticity leading to altered neural connectivity observed in these disorders. Changes in the expression or function of proteins like neurexins which interact with LRRTM2 can further contribute to disease pathologies. Understanding LRRTM2's role in these contexts could help identify therapeutic targets for modifying synaptic connectivity affected in such conditions.
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Specifications

Form

Lyophilized

Additional notes

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

Sequence similarities

Belongs to the LRRTM family.

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Product protocols

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Target data

Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
See full target information LRRTM2
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