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AB191983

Recombinant Human LSAMP protein

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Recombinant Human LSAMP protein is a Human Full Length protein, in the 29 to 315 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

IGLON3, LAMP, LSAMP, Limbic system-associated membrane protein, IgLON family member 3

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

Q13449

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"VRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFRPGSVRGINVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"32.86 kDa","actualMolecularWeight":null,"aminoAcidEnd":315,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q13449","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The limbic system-associated membrane protein (LSAMP) also known as IgLON5 is a protein with a mass of around 64 kDa. It is an important component of the neuronal membrane and found heavily expressed in the limbic system which includes areas like the hippocampus and amygdala. LSAMP localizes at synaptic junctions suggesting its active role in neuron-to-neuron communication. It belongs to the immunoglobulin superfamily and is known for facilitating cell adhesion processes in the brain.
Biological function summary

LSAMP influences the growth and connectivity of neurons. It plays an important role in neuronal development guiding axonal processes and stabilizing synaptic contacts. LSAMP does not function alone; it forms part of a complex with several other cell adhesion molecules working collaboratively to influence neural circuit formation and synaptic plasticity. These actions are important for the correct wiring of nerve cells during development and learning processes.

Pathways

LSAMP influences the cellular signaling related to growth and connectivity. It is active in pathways such as the MAPK signaling pathway which affects cell division survival and differentiation. LSAMP interacts with proteins like NCAM (neural cell adhesion molecule) and L1CAM (L1 cell adhesion molecule) which are significant in these pathways. These proteins work together to modulate molecular mechanisms that underlie neural network stability and response to environmental stimuli.

LSAMP has been connected to abnormalities in neural circuits leading to potential links with psychiatric disorders such as schizophrenia and anxiety. Research indicates that alterations in LSAMP expression or function can disrupt neural development and contribute to these disorders. It may act in conjunction with factors like BDNF (brain-derived neurotrophic factor) during disease pathogenesis highlighting the complex interactions that underpin these neurosignificant disorders.
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Specifications

Form

Lyophilized

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General info

Function

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).

Sequence similarities

Belongs to the immunoglobulin superfamily. IgLON family.

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Product protocols

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Target data

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
See full target information LSAMP
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