Recombinant Human LSAMP protein (His tag) is a Human Fragment protein, in the 1 to 315 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M V R R V Q P D R K Q L P L V L L R L L C L L P T G L P V R S V D F N R G T D N I T V R Q G D T A I L R C V V E D K N S K V A W L N R S G I I F A G H D K W S L D P R V E L E K R H S L E Y S L R I Q K V D V Y D E G S Y T C S V Q T Q H E P K T S Q V Y L I V Q V P P K I S N I S S D V T V N E G S N V T L V C M A N G R P E P V I T W R H L T P T G R E F E G E E E Y L E I L G I T R E Q S G K Y E C K A A N E V S S A D V K Q V K V T V N Y P P T I T E S K S N E A T T G R Q A S L K C E A S A V P A P D F E W Y R D D T R I N S A N G L E I K S T E G Q S S L T V T N V T E E H Y G N Y T C V A A N K L G V T N A S L V L F R P G S V R G I N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
Alternative names
IGLON3, LAMP, LSAMP, Limbic system-associated membrane protein, IgLON family member 3
Recommended products
Recombinant Human LSAMP protein (His tag) is a Human Fragment protein, in the 1 to 315 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q13449-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M V R R V Q P D R K Q L P L V L L R L L C L L P T G L P V R S V D F N R G T D N I T V R Q G D T A I L R C V V E D K N S K V A W L N R S G I I F A G H D K W S L D P R V E L E K R H S L E Y S L R I Q K V D V Y D E G S Y T C S V Q T Q H E P K T S Q V Y L I V Q V P P K I S N I S S D V T V N E G S N V T L V C M A N G R P E P V I T W R H L T P T G R E F E G E E E Y L E I L G I T R E Q S G K Y E C K A A N E V S S A D V K Q V K V T V N Y P P T I T E S K S N E A T T G R Q A S L K C E A S A V P A P D F E W Y R D D T R I N S A N G L E I K S T E G Q S S L T V T N V T E E H Y G N Y T C V A A N K L G V T N A S L V L F R P G S V R G I N
- Accession
- Q13449
- Protein length
- Fragment
- Predicted molecular weight
- 33.4 kDa
- Amino acids
- 1 to 315
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
- Sequence similarities
Belongs to the immunoglobulin superfamily. IgLON family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The limbic system-associated membrane protein (LSAMP) also known as IgLON5 is a protein with a mass of around 64 kDa. It is an important component of the neuronal membrane and found heavily expressed in the limbic system which includes areas like the hippocampus and amygdala. LSAMP localizes at synaptic junctions suggesting its active role in neuron-to-neuron communication. It belongs to the immunoglobulin superfamily and is known for facilitating cell adhesion processes in the brain.
- Biological function summary
LSAMP influences the growth and connectivity of neurons. It plays an important role in neuronal development guiding axonal processes and stabilizing synaptic contacts. LSAMP does not function alone; it forms part of a complex with several other cell adhesion molecules working collaboratively to influence neural circuit formation and synaptic plasticity. These actions are important for the correct wiring of nerve cells during development and learning processes.
- Pathways
LSAMP influences the cellular signaling related to growth and connectivity. It is active in pathways such as the MAPK signaling pathway which affects cell division survival and differentiation. LSAMP interacts with proteins like NCAM (neural cell adhesion molecule) and L1CAM (L1 cell adhesion molecule) which are significant in these pathways. These proteins work together to modulate molecular mechanisms that underlie neural network stability and response to environmental stimuli.
- Associated diseases and disorders
LSAMP has been connected to abnormalities in neural circuits leading to potential links with psychiatric disorders such as schizophrenia and anxiety. Research indicates that alterations in LSAMP expression or function can disrupt neural development and contribute to these disorders. It may act in conjunction with factors like BDNF (brain-derived neurotrophic factor) during disease pathogenesis highlighting the complex interactions that underpin these neurosignificant disorders.
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1 product image
SDS-PAGE - Recombinant Human LSAMP protein (His tag) (ab276463)
SDS-PAGE analysis of ab276463
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