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AB243774

Recombinant human LTA protein (Active)

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(1 Publication)

Recombinant human LTA protein (Active) is a Human Full Length protein, in the 35 to 205 aa range, expressed in Escherichia coli, with >96%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, HPLC.

View Alternative Names

TNFB, TNFSF1, LTA, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1

1 Images
SDS-PAGE - Recombinant human LTA protein (Active) (AB243774)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human LTA protein (Active) (AB243774)

SDS Page analysis of LTA with ab243774.

Key facts

Purity

>96% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

HPLC, SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/ml, corresponding to a specific activity of >2.0x108 IU/mg in the presence of actinomycin D.

Accession

P01374

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water or 0.1% BSA aqueous buffer

Storage buffer

Constituents: PBS, 0.02% Sorbitan monolaurate, ethoxylated

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as TNF beta
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Sequence info

[{"sequence":"LPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL","proteinLength":"Full Length","predictedMolecularWeight":"18.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":205,"aminoAcidStart":35,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P01374","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Lyophilized

Additional notes

> 96 % HPLC.

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General info

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed : 9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR (PubMed : 24248355). Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.

Sequence similarities

Belongs to the tumor necrosis factor family.

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Product protocols

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Target data

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed : 9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR (PubMed : 24248355). Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
See full target information LTA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Brain : a journal of neurology 145:4287-4307 PubMed35776111

2022

Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel E James Bates,Eleanor Browne,Renee Schalks,Heather Jacobs,Li Tan,Puja Parekh,Roberta Magliozzi,Massimiliano Calabrese,Nicholas D Mazarakis,Richard Reynolds
View all publications
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Product promise

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