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AB114738

Recombinant Human LTBP1 protein

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Recombinant Human LTBP1 protein is a Human Fragment protein, in the 403 to 500 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1, LTBP1

1 Images
SDS-PAGE - Recombinant Human LTBP1 protein (AB114738)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human LTBP1 protein (AB114738)

12.5% SDS-PAGE showing ab114738 at approximately 36.41kDa.
Stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q14766

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein)</p>" } } }
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Sequence info

[{"sequence":"CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLS","proteinLength":"Fragment","predictedMolecularWeight":"36.41 kDa","actualMolecularWeight":null,"aminoAcidEnd":500,"aminoAcidStart":403,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q14766","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LTBP1 or Latent Transforming Growth Factor Beta Binding Protein 1 mechanically acts as an important regulator in the activation and release of Transforming Growth Factor Beta (TGF-β). It is part of the latent TGF-β complex binding to TGF-β to help control its availability in the extracellular matrix. LTBP1 has a molecular weight of approximately 190 kDa. The protein is expressed in many tissues including the lung skin and heart highlighting its widespread role in various physiological processes.
Biological function summary

Its main role is modulating the bioavailability and activity of TGF-β a protein important to cellular differentiation proliferation and apoptosis. As part of a larger latent TGF-β complex it determines the precise activation and function of TGF-β by anchoring it to the extracellular matrix. This regulation is important for maintaining tissue homeostasis and has implications in developmental and repair processes across different organ systems.

Pathways

LTBP1 plays a significant role in the TGF-β signaling pathway which is important for controlling cellular growth and differentiation. It is involved in linking TGF-β to large latent complexes impacting its sequestration and activation within the matrix. Through this pathway LTBP1 interacts with proteins such as integrins which help release the active form of TGF-β furthering downstream signaling activities.

LTBP1 is implicated in fibrotic diseases and certain cancers. Abnormal expression or function of LTBP1 can lead to dysregulation of TGF-β activity causing excessive tissue fibrosis as seen in systemic sclerosis or contributing to the progression of cancers like lung carcinoma. The interaction of LTBP1 with other proteins particularly integrins can exacerbate these conditions by derailing typical matrix remodeling and cellular signaling processes.
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Specifications

Form

Liquid

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General info

Function

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed : 2022183, PubMed : 8617200, PubMed : 8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed : 15184403, PubMed : 8617200, PubMed : 8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed : 22278742).

Sequence similarities

Belongs to the LTBP family.

Post-translational modifications

Contains hydroxylated asparagine residues.. Isoform Short N-terminus is blocked.. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.. O-glycosylated on serine residues by POGLUT2 and POGLUT3.

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Product protocols

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Target data

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed : 2022183, PubMed : 8617200, PubMed : 8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed : 15184403, PubMed : 8617200, PubMed : 8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed : 22278742).
See full target information LTBP1
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