Recombinant Human LTBP2 protein is a Human Fragment protein, in the 1709 to 1818 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
L Q P S E L Q P H Y V A S H P E P P A G F E G L Q A E E C G I L N G C E N G R C V R V R E G Y T C D C F E G F Q L D A A H M A C V D V N E C D D L N G P A V L C V H G Y C E N T E G S Y R C H C S P G Y V A E A G P P H C T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
Alternative names
C14orf141, LTBP3, LTBP2, Latent-transforming growth factor beta-binding protein 2, LTBP-2
Recommended products
Recombinant Human LTBP2 protein is a Human Fragment protein, in the 1709 to 1818 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q14767-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- L Q P S E L Q P H Y V A S H P E P P A G F E G L Q A E E C G I L N G C E N G R C V R V R E G Y T C D C F E G F Q L D A A H M A C V D V N E C D D L N G P A V L C V H G Y C E N T E G S Y R C H C S P G Y V A E A G P P H C T
- Accession
- Q14767
- Protein length
- Fragment
- Amino acids
- 1709 to 1818
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly.
- Sequence similarities
Belongs to the LTBP family.
- Post-translational modifications
N-Glycosylated.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LTBP2 also known as latent transforming growth factor-beta binding protein 2 is a glycoprotein involved in the regulation of transforming growth factor-beta (TGF-β) signaling. This protein has a mass of approximately 195 kDa. LTBP2 is expressed in a variety of tissues including the lungs heart and eyes. It plays an important role in the extracellular matrix where it is fundamental to the sequestration and subsequent activation of TGF-β.
- Biological function summary
LTBP2 interacts with the extracellular matrix components and acts as a structural protein. LTBP2 is an important part of TGF-β complexes. By anchoring TGF-β in a latent form it controls the availability and activation of TGF-β which is necessary for processes like cell growth differentiation and tissue repair. Without LTBP2 the controlled release of TGF-β can be disrupted impacting various cell functions.
- Pathways
LTBP2 regulates the TGF-β signaling pathway and maintains its equilibrium. This regulatory function links LTBP2 to the pathways involving cell proliferation and differentiation. LTBP2 closely interacts with other members of the LTBP family as well as proteins like fibrillin which are involved in the structural integrity of the extracellular matrix. These interactions are significant for maintaining proper signal transduction and cellular responses.
- Associated diseases and disorders
LTBP2 mutations have associations with conditions such as glaucoma and Weill-Marchesani syndrome. In glaucoma abnormalities in LTBP2 might affect the integrity of the extracellular matrix influencing intraocular pressure regulation. It also connects to fibrillin-related disorders due to its interaction with fibrillin proteins. These associations highlight the importance of LTBP2 in both structural and signaling roles within the body.
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1 product image
SDS-PAGE - Recombinant Human LTBP2 protein (ab158832)
ab158832 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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