Recombinant Human LXN/TCI protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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- World journal of surgical oncology 12:4042014Latexin inhibits the proliferation of CD133+ miapaca-2 pancreatic cancer stem-like cells.Applications:FuncSReactive species:Unspecified reactive speciesZhan-Xiong Xue,Ji-Hang Zheng,Zhi-Qiang Zheng,Jing-Li Cai,Xiao-Hua Ye,Cheng Wang,Wei-Jian Sun,Xiang Zhou,Ming-Dong Lu,Pi-Hong Li,Zhen-Zhai CaiPubMed 25551472
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M E I P P T N Y P A S R A A L V A Q N Y I N Y Q Q G T P H R V F E V Q K V K Q A S M E D I P G R G H K Y R L K F A V E E I I Q K Q V K V N C T A E V L Y P S T G Q E T A P E V N F T F E G E T G K N P D E E D N T F Y Q R L K S M K E P L E A Q N I P D N F G N V S P E M T L V L H L A W V A C G Y I I W Q N S T E D T W Y K M V K I Q T V K Q V Q R N D D F I E L D Y T I L L H N I A S Q E I I P W Q M Q V L W H P Q Y G T K V K H N S R L P K E V Q L E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
Alternative names
Latexin, Endogenous carboxypeptidase inhibitor, Protein MUM, Tissue carboxypeptidase inhibitor, ECI, TCI, LXN
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Recombinant Human LXN/TCI protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9BS40-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride
Sequence info
Amino acid sequence
- M E I P P T N Y P A S R A A L V A Q N Y I N Y Q Q G T P H R V F E V Q K V K Q A S M E D I P G R G H K Y R L K F A V E E I I Q K Q V K V N C T A E V L Y P S T G Q E T A P E V N F T F E G E T G K N P D E E D N T F Y Q R L K S M K E P L E A Q N I P D N F G N V S P E M T L V L H L A W V A C G Y I I W Q N S T E D T W Y K M V K I Q T V K Q V Q R N D D F I E L D Y T I L L H N I A S Q E I I P W Q M Q V L W H P Q Y G T K V K H N S R L P K E V Q L E
- Accession
- Q9BS40
- Protein length
- Full Length
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab87145 was purified using conventional chromatography.Endotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method )
General info
- Function
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
- Sequence similarities
Belongs to the protease inhibitor I47 (latexin) family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Protein previously labeled as LXN.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LXN also known as Latexin or TCI (Tryptase Inhibitor Complex) is a protein with a molecular mass of approximately 24 kDa. LXN acts as an inhibitor of carboxypeptidase A and is primarily involved in regulating protease activity. It is expressed mainly in the liver lung and kidney playing a significant role in protein degradation processes. LXN's inhibitory functions contribute significantly to cellular processes by modulating enzyme activity.
- Biological function summary
LXN influences cell proliferation and differentiation. It participates in cellular protection mechanisms against enzymatic damage and balances protease and anti-protease activities in tissues. Although not part of a large complex LXN impacts various cellular events through its protease inhibitor function making it important in tissue homeostasis. Studies suggest its importance in maintaining cell viability and regulating cellular stress responses.
- Pathways
LXN associates with pathways linked to inflammation and tissue remodeling with particular emphasis on the protease-antiprotease balance. LXN acts within the kallikrein-kinin system and relates to proteins such as carboxypeptidase A1 which it directly inhibits. Its modulation of these pathways is essential for normal physiological responses and protective mechanisms against tissue damage.
- Associated diseases and disorders
LXN has been linked to cancer and inflammation-related conditions. In cancer its regulation of protease activity can influence tumor growth and metastasis often interacting with proteins like tryptase. LXN's role in inflammation relates to conditions such as rheumatoid arthritis where its influence on the balance of proteases and inhibitors impacts tissue damage and repair processes. Further research into LXN's roles may help elucidate mechanisms driving these diseases offering potential therapeutic targets.
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1 product image
SDS-PAGE - Recombinant Human LXN/TCI protein (ab87145)
15% SDS-PAGE showing ab87145 (3ug)
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