Recombinant Human LYPD3 protein (His tag) is a Human Fragment protein, in the 1 to 286 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
M D P A R K A G A Q A M I W T A G W L L L L L L R G G A Q A L E C Y S C V Q K A D D G C S P N K M K T V K C A P G V D V C T E A V G A V E T I H G Q F S L A V R G C G S G L P G K N D R G L D L H G L L A F I Q L Q Q C A Q D R C N A K L N L T S R A L D P A G N E S A Y P P N G V E C Y S C V G L S R E A C Q G T S P P V V S C Y N A S D H V Y K G C F D G N V T L T A A N V T V S L P V R G C V Q D E F C T R D G V T G P G F T L S G S C C Q G S R C N S D L R N K T Y F S P R I P P L V R L P P P E P T T V A S T T S V T T S T S A P V R P T S T T K P M P A P T S Q T P R Q G V E H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Alternative names
Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, UNQ491/PRO1007, C4.4A, LYPD3
Recommended products
Recombinant Human LYPD3 protein (His tag) is a Human Fragment protein, in the 1 to 286 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, UNQ491/PRO1007, C4.4A, LYPD3
Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- O95274-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
M D P A R K A G A Q A M I W T A G W L L L L L L R G G A Q A L E C Y S C V Q K A D D G C S P N K M K T V K C A P G V D V C T E A V G A V E T I H G Q F S L A V R G C G S G L P G K N D R G L D L H G L L A F I Q L Q Q C A Q D R C N A K L N L T S R A L D P A G N E S A Y P P N G V E C Y S C V G L S R E A C Q G T S P P V V S C Y N A S D H V Y K G C F D G N V T L T A A N V T V S L P V R G C V Q D E F C T R D G V T G P G F T L S G S C C Q G S R C N S D L R N K T Y F S P R I P P L V R L P P P E P T T V A S T T S V T T S T S A P V R P T S T T K P M P A P T S Q T P R Q G V E H
- Accession
- Protein length
Fragment
- Predicted molecular weight
28.3 kDa
- Amino acids
1 to 286
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Lyophilized
General info
- Function
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
- Post-translational modifications
N-glycosylated and O-glycosylated.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
LYPD3 also known as C4.4A is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 40 kDa. It belongs to the Ly6/PLAUR domain family. This protein is mainly expressed in stratified epithelia and also found in some other tissues. LYPD3 shows higher expression levels in certain cancer cell types indicating its role in tumorigenesis.
- Biological function summary
LYPD3 functions in cellular adhesion and migration processes. It interacts with extracellular matrix components facilitating the movement and positioning of cells. It acts as a part of a protein complex that is important for cell communication and tissue organization. Its high expression in some cancer types suggests its involvement in processes that drive cancer progression including metastasis.
- Pathways
LYPD3 participates in key signaling cascades including integrin-mediated pathways. These pathways are important for mediating cell-matrix interactions and influence cell movement and survival. LYPD3 has known interactions with integrin proteins suggesting a collaborative role that modulates cell adhesion dynamics. These interactions make it an important player in cell migration and invasion processes that are pivotal for normal physiological events and pathological conditions.
- Associated diseases and disorders
LYPD3 shows significant involvement in cancers such as squamous cell carcinoma and prostate cancer. The protein aids the metastatic spread of these cancers by promoting cell migration and invasion. It has been associated with other proteins like laminin which supports cancer cell detachment and dissemination. Understanding LYPD3's role in cancer biology helps in identifying therapeutic targets for impeding cancer progression.
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SDS-PAGE - Recombinant Human LYPD3 protein (His tag) (ab276436)
SDS-PAGE analysis of ab276436
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