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AB182803

Recombinant Human M Cadherin protein

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Recombinant Human M Cadherin protein is a Human Fragment protein, in the 61 to 246 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

CDH14, CDH3, CDH15, Cadherin-15, Cadherin-14, Muscle cadherin, M-cadherin

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

T7 tag N-Terminus His tag N-Terminus TEV tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55291

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Secondary Antibodies

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Proteins & Peptides

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Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHGNLYFQGGEFLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAWAHNSRNLVAAALRVVAVAVVVAAVAN","proteinLength":"Fragment","predictedMolecularWeight":"26.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":246,"aminoAcidStart":61,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55291","tags":[{"tag":"T7","terminus":"N-Terminus"},{"tag":"His","terminus":"N-Terminus"},{"tag":"TEV","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

M-Cadherin also known as CDH15 is a member of the cadherin superfamily. This calcium-dependent cell adhesion molecule is approximately 100 kilodaltons in mass. M-Cadherin is expressed mostly in muscle tissues where it plays a role in cell recognition and connection processes. The presence of this protein on the cell surface helps in forming intercellular junctions contributing to the stabilization of cell interactions which are essential for developmental and repair functions in muscle cells.
Biological function summary

M-Cadherin facilitates cell-cell adhesion which is vital for the proper alignment of muscle cells during development and repair. This protein is a critical component of the adherens junction complex. During muscle regeneration M-Cadherin helps satellite cells to adhere to existing muscle fibers promoting the fusion needed for effective muscle repair. It operates alongside other proteins including β-catenin and α-catenin which link cadherins to the actin cytoskeleton reinforcing structural integrity.

Pathways

Different cellular processes involve M-Cadherin playing a role in the Wnt signaling and Notch signaling pathways. Wnt signaling is significant in muscle development and regeneration. M-Cadherin interacts with β-catenin in this pathway balancing the regulation of cellular adhesion and signaling events. In the Notch signaling pathway M-Cadherin influences satellite cell activation and proliferation helping maintain muscle stem cell populations which are important under conditions requiring muscle repair.

M-Cadherin has implications in muscle-related conditions such as muscular dystrophy and muscle degeneration. The protein's malfunction can result in impaired cell adhesion leading to defects in muscle repair mechanisms. In muscular dystrophy M-Cadherin-related disruptions are observed often together with abnormal β-catenin interactions. These disruptions contribute to inadequate muscle regeneration and muscular weakness underlining M-Cadherin's importance in maintaining muscle health.
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Specifications

Form

Liquid

Additional notes

ab182803 is expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.

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General info

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

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Product protocols

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
See full target information CDH15
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