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AB235855

Recombinant Human MA2 protein (Tagged)

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Recombinant Human MA2 protein (Tagged) is a Human Fragment protein, in the 2 to 361 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

KIAA0883, MA2, PNMA2, Paraneoplastic antigen Ma2, 40 kDa neuronal protein, Onconeuronal antigen Ma2, Paraneoplastic neuronal antigen MM2

1 Images
SDS-PAGE - Recombinant Human MA2 protein (Tagged) (AB235855)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MA2 protein (Tagged) (AB235855)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab235855.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UL42

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Complementary Products

Primary Antibodies

AB234740

Anti-MA2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MA2 antibody (AB234740)

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Primary Antibodies

AB137093

Anti-RAB22A antibody [EPR9486]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-RAB22A antibody [EPR9486] (AB137093)

  • 0
  • 0
Biochemicals

AB146296

Xylene cyanol FF, tracking dye for nucleic acids

Chemical Structure - Xylene cyanol FF, tracking dye for nucleic acids (AB146296)

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  • 0
Proteins & Peptides

AB158120

Recombinant Human CHRNB4 protein

SDS-PAGE - Recombinant Human CHRNB4 protein (AB158120)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE","proteinLength":"Fragment","predictedMolecularWeight":"57.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":361,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UL42","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MA2 also known as PNMA2 (Paraneoplastic Ma antigen 2) is a protein with a mass of approximately 57 kDa. It is primarily expressed in brain tissues and shows significant expression in neurons. The precise mechanism of action for MA2 involves its role in cellular processes that are yet to be fully detailed but its expression pattern hints at an importance in neuronal function. Furthermore due to its expression MA2 serves as an important target for researching neuronal diseases and autoimmune responses.
Biological function summary

MA2 plays an important role in the nervous system. It is part of a complex known as neuron-specific RNA-binding proteins which are critical for the regulation of mRNA transport and translation in neurons. MA2 interacts directly with other proteins within this complex to enable proper neural function affecting synaptic plasticity and neuron survival. This involvement suggests that MA2 has functions critical to maintaining normal neurological activity.

Pathways

The protein MA2 interacts with important signaling networks such as the MAPK/ERK pathway and PI3K/AKT pathway. These pathways are essential for neurodevelopment cell survival and synaptic functions. MA2’s interaction with proteins like ERK1/2 and AKT suggests it plays a role in the modulation of these pathways impacting cellular communication and the overall neuronal response to external stimuli.

MA2 is associated with conditions such as paraneoplastic neurological syndromes and certain types of cancer. Anti-MA2 antibodies are frequently found in patients with paraneoplastic limbic encephalitis a condition where the immune system mistakenly attacks the brain tissue. Proteins like HuD also connect to MA2 through these neurological disorders as they share similar immune target profiles in affected individuals reflecting autoimmune responses contributing to disease pathology.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the PNMA family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

See full target information PNMA2
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Product promise

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