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AB204143

Recombinant Human MADM protein

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Recombinant Human MADM protein is a Human Full Length protein, in the 1 to 535 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE.

View Alternative Names

BCON3, NRBP, NRBP1, Nuclear receptor-binding protein

1 Images
SDS-PAGE - Recombinant Human MADM protein (AB204143)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MADM protein (AB204143)

SDS-PAGE analysis of ab204143.

Key facts

Purity

>90% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UHY1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS","proteinLength":"Full Length","predictedMolecularWeight":"92 kDa","actualMolecularWeight":null,"aminoAcidEnd":535,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9UHY1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Misexpression Affecting Delta Microtubule (MADM) protein also known as 'mαδμ' is involved in the regulation of microtubule dynamics important for cellular structure and transport. This protein although its precise molecular weight is not well-documented generally localizes within cells that actively undergo division and differentiation across various tissues. The expression of MADM can vary significantly often reflecting the differentiation status of the cell and tissue involved.
Biological function summary

MADM interacts with several cellular proteins helping to orchestrate the assembly and disassembly of microtubules. It does not function in isolation and often forms complexes with other proteins to effectively manage its roles. Through these interactions MADM ensures proper cell division and migration key processes in maintaining cellular integrity and tissue development.

Pathways

MADM integrates into the signaling networks governing the cytoskeleton. It participates in the microtubule-organizing center (MTOC) pathways and is associated with the mitotic spindle organization. During these processes MADM interacts with proteins like α-tubulin and β-tubulin facilitating spindle functionality essential for accurate chromosome segregation during mitosis.

Abnormal expression or mutation in MADM has correlations with certain cancers such as breast and ovarian cancer. This association likely involves its link with tumor suppressor proteins like p53 and BRCA1. Dysregulation in MADM affects the maintenance of genomic stability contributing to oncogenesis and highlighting its therapeutic potential as a target in cancer treatment strategies.
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Specifications

Form

Liquid

Additional notes

Assessed by densitometry. Affinity purified.

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General info

Function

Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed : 11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed : 15084397).

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

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Product protocols

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Target data

Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed : 11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed : 15084397).
See full target information NRBP1
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