Recombinant Human MAEA protein (denatured)
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Recombinant Human MAEA protein (denatured) is a Human Full Length protein, in the 1 to 396 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
EMP, HLC10, PIG5, MAEA, E3 ubiquitin-protein transferase MAEA, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, Macrophage erythroblast attacher, P44EMLP, HLC-10
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MAEA protein (denatured) (AB167902)
15% SDS-PAGE analysis of 3µg ab167902.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MAEA plays a significant role in hematopoiesis by facilitating communication between macrophages and erythroblasts. It forms part of a protein complex that ensures the stability and viability of developing erythrocytes. This protein interaction is critical for the normal maturation of red blood cells helping to maintain the balance and production of these cells under varying physiological conditions.
Pathways
MAEA participates in the erythrophagocytosis and erythroblast enucleation processes. MAEA contributes to the interaction with proteins such as ICAM-4 and VLA-4 which are important in these pathways. Through these interactions MAEA is instrumental in effectively mediating red blood cell clearance and differentiation ensuring the proper function of erythroblastic islands within the bone marrow niche.
Specifications
Form
Liquid
General info
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed : 29911972). MAEA is required for normal cell proliferation (PubMed : 29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed : 29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed : 9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).
Post-translational modifications
Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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