Recombinant Human MAG1 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

MAG1 performs critical roles in base excision repair processes a vital step in fixing DNA single-strand breaks. Its activity involves participation as part of a multi-protein complex including MSH2 and other repair proteins ensuring the fidelity of DNA replication. This function helps prevent mutations that could lead to genomic instability which is important for normal cell cycle progression and apoptosis.

Pathways

The MAG1 protein integrates into the DNA mismatch repair and base excision repair pathways. It collaborates with proteins such as MSH2 and MLH1 in the mismatch repair pathway. These pathways provide defense mechanisms against spontaneous DNA damage and errors that occur during DNA replication. MAG1's association with these pathways underlines its significance in safeguarding cellular DNA from genotoxic stress.