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AB235805

Recombinant Human MAGEA10 protein (His tag)

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Recombinant Human MAGEA10 protein (His tag) is a Human Full Length protein, in the 1 to 369 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

MAGE10, MAGEA10, Melanoma-associated antigen 10, Cancer/testis antigen 1.10, MAGE-10 antigen, CT1.10

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SDS-PAGE - Recombinant Human MAGEA10 protein (His tag) (AB235805)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MAGEA10 protein (His tag) (AB235805)

ab235805 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

10x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P43363

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPRAPKRQRCMPEEDLQSQSETQGLEGAQAPLAVEEDASSSTSTSSSFPSSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASLPLDQSDEGSSSQKEESPSTLQVLPDSESLPRSEIDEKVTDLVQFLLFKYQMKEPITKAEILESVIRNYEDHFPLLFSEASECMLLVFGIDVKEVDPTGHSFVLVTSLGLTYDGMLSDVQSMPKTGILILILSIVFIEGYCTPEEVIWEALNMMGLYDGMEHLIYGEPRKLLTQDWVQENYLEYRQVPGSDPARYEFLWGPRAHAEIRKMSLLKFLAKVNGSDPRSFPLWYEEALKDEEERAQDRIATTDDTTAMASASSSATGSFSYPE","proteinLength":"Full Length","predictedMolecularWeight":"46.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":369,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P43363","tags":[{"tag":"10x His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA10 also known as Melanoma Antigen Family A 10 is a member of the MAGE (Melanoma Antigen Gene) family. This protein has a molecular mass of about 36 kDa. MAGEA10 is expressed in various tumor cells and some male germline cells in the testis but not in normal somatic tissues. The expression pattern makes it an interesting target for cancer research and potential therapeutic interventions.
Biological function summary

The function of MAGEA10 remains not fully understood but it likely plays a role in cell proliferation and survival. It is not a component of any known protein complex. Research suggests that MAGEA10 might modulate cellular processes by interacting with other proteins impacting pathways related to oncogenesis and cell cycle regulation.

Pathways

MAGEA10 appears to be involved in critical pathways associated with cancer progression and possibly immune evasion. It interacts with proteins involved in cell signaling pathways such as the p53 pathway which is pivotal in regulating the cell cycle and apoptosis. MAGEA10 may influence these pathways by affecting gene transcription and modulating protein-protein interactions.

MAGEA10 has a strong connection to cancer particularly in melanoma and lung cancer. Overexpression of MAGEA10 in these cancers suggests a possible role in tumor growth and metastasis. The protein is part of cancer-testis antigens similar to MAGEA1 another member of the same family implicated in various malignancies suggesting that targeting MAGEA10 could aid in developing specific cancer immunotherapies.
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Specifications

Form

Liquid

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General info

Function

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
See full target information MAGEA10
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Product promise

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