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AB99138

Recombinant Human MAGEA4 protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human MAGEA4 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 317 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MAGE4, MAGEA4, Melanoma-associated antigen 4, Cancer/testis antigen 1.4, MAGE-4 antigen, MAGE-41 antigen, MAGE-X2 antigen, CT1.4

1 Images
SDS-PAGE - Recombinant Human MAGEA4 protein (AB99138)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAGEA4 protein (AB99138)

15% SDS-PAGE analysis of 3μg ab99138

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P43358

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPTSNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV","proteinLength":"Full Length","predictedMolecularWeight":"37 kDa","actualMolecularWeight":null,"aminoAcidEnd":317,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P43358","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA4 also known as MAGE-A4 is part of the melanoma-associated antigen family. This protein is encoded by the MAGEA4 gene and is characterized by a molecular mass of approximately 42 kDa. Its expression is limited to certain tissues including the testis and is often silent in normal somatic tissues. However MAGEA4 is frequently found in various types of tumors making it a target of interest for cancer research and therapy.
Biological function summary

MAGEA4 participates in cellular processes related to cancer progression. Although not part of a multi-protein complex its presence in tumorous tissues suggests a role in modulating cellular mechanisms that favor tumor survival and proliferation. MAGEA4 does not directly interact with other proteins but might affect cellular pathways indirectly contributing to oncogenesis.

Pathways

MAGEA4 influences several cellular mechanisms that are related to cancer development. While it is not a central player in major biological pathways its function relates to processes affecting cell cycle regulation and apoptosis. This connection was observed in studies showing interactions with other cancer-related proteins like p53 suggesting that MAGEA4 can modify responses to apoptotic signals and may interact with or affect the TP53 pathway.

MAGEA4 is prominently linked to various cancers including melanomas and carcinomas such as lung cancer. Its frequent expression in tumor cells but not in normal tissues makes MAGEA4 a target for cancer immunotherapy. Additionally studies have shown that MAGEA4 may interfere with the immune system's ability to detect and destroy cancerous cells partly due to interactions with proteins like CTLA-4 further emphasizing its potential as a therapeutic target in oncology.
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Specifications

Form

Liquid

Additional notes

ab99138 was purified using conventional chromatography.

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General info

Function

Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed : 22842486). Also negatively regulates p53-mediated apoptosis (PubMed : 22842486).

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Product protocols

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Target data

Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed : 22842486). Also negatively regulates p53-mediated apoptosis (PubMed : 22842486).
See full target information MAGEA4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eads4227 PubMed39937892

2025

MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.

Applications

Unspecified application

Species

Unspecified reactive species

Dominique Armstrong,Cheng-Yen Chang,Monica J Hong,Linda Green,Yichao Shen,William Hudson,Kelsey E Mauk,Li-Zhen Song,Sheetal Jammi,Benjamin Casal,Brianna Burns,Chad J Creighton,Alexandre Carisey,Xiang H-F Zhang,Neil J McKenna,Sung Wook Kang,Hyun-Sung Lee,William Decker,David B Corry,Farrah Kheradmand
View all publications
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