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AB126656

Recombinant Human MAGEA6 protein (His tag C-Terminus)

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(1 Publication)

Recombinant Human MAGEA6 protein (His tag C-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MAGE6, MAGEA6, Melanoma-associated antigen 6, Cancer/testis antigen 1.6, MAGE-6 antigen, MAGE3B antigen, CT1.6

1 Images
SDS-PAGE - Recombinant Human MAGEA6 protein (His tag C-Terminus) (AB126656)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAGEA6 protein (His tag C-Terminus) (AB126656)

15% SDS-PAGE showing ab126656 (3µg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P43360

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEELEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"35.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P43360","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA6 also known as Melanoma Antigen Family A6 is a member of the MAGE gene family. This protein has a molecular mass of approximately 35 kDa. MAGEA6 is usually expressed in the testis and various types of tumors but shows limited expression in normal somatic tissues. Its expression in tumors makes it a potential target for cancer immunotherapy and biomarker research.
Biological function summary

MAGEA6 is involved in cellular processes relating to gene regulation and apoptosis. It interacts with other MAGE proteins and is often part of a larger multiprotein complex which influences gene transcription. The protein plays a role in cell survival and proliferation particularly in tumorous cells where it can aid in escape from immune surveillance.

Pathways

MAGEA6 participates in critical signaling pathways including the p53 pathway. This pathway is significant in regulating cell cycle arrest DNA repair and apoptosis. MAGEA6 can interact with proteins like p53 and MDM2 potentially modulating the tumor suppressor functions of p53. This interaction highlights its role in tumor pathogenesis as it can affect cell cycle regulation and apoptosis resistance.

MAGEA6 associates closely with cancers such as melanoma and ovarian cancer. Its expression in these cancers connects it to proteins like MAGEA1 and MAGEA3 which also have roles in cancer biology and immune evasion. The presence of MAGEA6 in tumors offers potential for it to be used as a cancer-specific antigen in various therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab126656 is purified using conventional chromatography techniques

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General info

Function

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed : 17942928, PubMed : 20864041, PubMed : 31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex (PubMed : 17942928, PubMed : 20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed : 17942928, PubMed : 20864041). In vitro promotes cell viability in melanoma cell lines (PubMed : 17942928).

Post-translational modifications

Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.

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Product protocols

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Target data

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed : 17942928, PubMed : 20864041, PubMed : 31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex (PubMed : 17942928, PubMed : 20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed : 17942928, PubMed : 20864041). In vitro promotes cell viability in melanoma cell lines (PubMed : 17942928).
See full target information MAGEA6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed39409926

2024

ANKRD1 Promotes Breast Cancer Metastasis by Activating NF-B-MAGE-A6 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Penchatr Diskul-Na-Ayudthaya,Seon Joo Bae,Yun-Ui Bae,Ngu Trinh Van,Wootae Kim,Seongho Ryu
View all publications
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