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AB176031

Recombinant Human MAGEB10 protein (His tag N-Terminus)

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Recombinant Human MAGEB10 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 347 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Melanoma-associated antigen B10, MAGE-B10 antigen, MAGEB10

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SDS-PAGE - Recombinant Human MAGEB10 protein (His tag N-Terminus) (AB176031)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MAGEB10 protein (His tag N-Terminus) (AB176031)

15% SDS-PAGE analysis of ab176031 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q96LZ2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPRGQKSKLRAREKRRQARGGLEDLIDALDILEEEEESPPSASACLKDVFQSSLDGASNNPHGLREAQSTSTSATAASHTRHPEGVNDQMEERPICTQDLEATDSFPRGPVDEKVIILVHYLLYKYQMKEPITKADMLRNVTQMSKSQFPVILSRASEHLELIFGLDLKEVEPNKHIYVLVNKLDLGCDAKLSDETGVPKTGLLMTVLGIIFTNGNCVAEEEVWKVFNTMGLYDGIEHFMFGEPRKLLTKDLVKENYLEYQQVPNSDPPRYQFLWGPRAHAETSKMKVLEFLAKVNDTAPSEFSNWYTEALQDEEERARARVAAKARVSATAGARSKVKSSKSSQLQ","proteinLength":"Full Length","predictedMolecularWeight":"41.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":347,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96LZ2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEB10 also known as Melanoma Antigen Family B10 belongs to the MAGE family of proteins. This protein has a mass of approximately 40 kDa. MAGEB10 is typically expressed in testis and certain cancerous tissues. It mechanistically interacts with microtubules suggesting a role in cellular structure and motility.
Biological function summary

This protein assists in cellular processes related to proliferation and differentiation. MAGEB10 functions as part of a complex that influences gene transcription regulation. While not fully understood its presence in several tissues indicates it might play roles beyond reproductive biology potentially in tumorigenic processes.

Pathways

Several mechanisms involve MAGEB10 notably the p53 signaling pathway. This protein interacts with p53 an important tumor suppressor affecting apoptosis regulation and cell cycle control. MAGEB10 shares pathway interactions with proteins like MDM2 which further regulates p53 activities emphasizing its role in tumor biology.

Researchers have linked MAGEB10 to certain cancers like melanoma and bladder cancer. Studies show that this protein can interact with tumor-associated antigens such as NY-ESO-1 enhancing its potential as a target for cancer immunotherapy. Understanding these associations helps in developing novel diagnostic and therapeutic approaches.
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Specifications

Form

Liquid

Additional notes

ab176031 is purified using conventional chromatography techniques

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General info

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Product protocols

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Target data

See full target information MAGEB10
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