Recombinant Human MAGEH1 protein is a Human Full Length protein, in the 1 to 219 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M P R G R K S R R R R N A R A A E E N R N N R K I Q A S E A S E T P M A A S V V A S T P E D D L S G P E E D P S T P E E A S T T P E E A S S T A Q A Q K P S V P R S N F Q G T K K S L L M S I L A L I F I M G N S A K E A L V W K V L G K L G M Q P G R Q H S I F G D P K K I V T E E F V R R G Y L I Y K P V P R S S P V E Y E F F W G P R A H V E S S K L K V M H F V A R V R N R C S K D W P C N Y D W D S D D D A E V E A I L N S G A R G Y S A P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
APR1, MAGEH1, Melanoma-associated antigen H1, Apoptosis-related protein 1, MAGE-H1 antigen, Restin, APR-1
Recommended products
Recombinant Human MAGEH1 protein is a Human Full Length protein, in the 1 to 219 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9H213-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M P R G R K S R R R R N A R A A E E N R N N R K I Q A S E A S E T P M A A S V V A S T P E D D L S G P E E D P S T P E E A S T T P E E A S S T A Q A Q K P S V P R S N F Q G T K K S L L M S I L A L I F I M G N S A K E A L V W K V L G K L G M Q P G R Q H S I F G D P K K I V T E E F V R R G Y L I Y K P V P R S S P V E Y E F F W G P R A H V E S S K L K V M H F V A R V R N R C S K D W P C N Y D W D S D D D A E V E A I L N S G A R G Y S A P
- Accession
- Q9H213
- Protein length
- Full Length
- Amino acids
- 1 to 219
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MAGEH1 also known as Melanoma Antigen Family H1 is a member of the MAGE (Melanoma Antigen Gene) family of proteins. The mass of MAGEH1 is approximately 35 kDa. It is expressed in various tissues showing a notable expression in the brain and testis. MAGEH1 is cytoplasmic in normal conditions and can translocate to the nucleus under specific circumstances. Its expression can vary especially in certain cancerous conditions.
- Biological function summary
MAGEH1 is implicated in cellular processes such as cell cycle regulation and apoptosis. Researchers know that it may interact with other proteins forming part of a larger protein complex. This complex can influence the regulation of gene expression although the exact partners of MAGEH1 in these interactions remain an active area of research. MAGEH1's roles in these cellular processes suggest its involvement in controlling cellular growth and death.
- Pathways
Several aspects beyond MAGEH1 indicate its functions within important biological pathways like p53 and the apoptotic pathways. MAGEH1 can interact with proteins such as p53 which is pivotal in the maintenance of genomic stability and cell cycle arrest. These interactions highlight the role of MAGEH1 in apoptosis and cellular response to stress. In addition its interaction with members of the Bcl-2 family further supports its involvement in apoptotic pathways.
- Associated diseases and disorders
Multiple studies link MAGEH1 with cancer and neurodegenerative diseases. In certain cancers overexpression or malfunction of MAGEH1 correlates with tumor progression and poor prognosis. MAGEH1 might interact with E3 ubiquitin-protein ligases like MDM2 which regulates p53 levels and can contribute to tumorigenesis when dysregulated. Research also suggests a potential role in neurodegenerative diseases where altered expression of MAGE family proteins influences neural health.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human MAGEH1 protein (ab162198)
ab162198 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com