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AB162198

Recombinant Human MAGEH1 protein

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Recombinant Human MAGEH1 protein is a Human Full Length protein, in the 1 to 219 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

APR1, MAGEH1, Melanoma-associated antigen H1, Apoptosis-related protein 1, MAGE-H1 antigen, Restin, APR-1

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SDS-PAGE - Recombinant Human MAGEH1 protein (AB162198)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human MAGEH1 protein (AB162198)

ab162198 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9H213

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPRGRKSRRRRNARAAEENRNNRKIQASEASETPMAASVVASTPEDDLSGPEEDPSTPEEASTTPEEASSTAQAQKPSVPRSNFQGTKKSLLMSILALIFIMGNSAKEALVWKVLGKLGMQPGRQHSIFGDPKKIVTEEFVRRGYLIYKPVPRSSPVEYEFFWGPRAHVESSKLKVMHFVARVRNRCSKDWPCNYDWDSDDDAEVEAILNSGARGYSAP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":219,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H213","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEH1 also known as Melanoma Antigen Family H1 is a member of the MAGE (Melanoma Antigen Gene) family of proteins. The mass of MAGEH1 is approximately 35 kDa. It is expressed in various tissues showing a notable expression in the brain and testis. MAGEH1 is cytoplasmic in normal conditions and can translocate to the nucleus under specific circumstances. Its expression can vary especially in certain cancerous conditions.
Biological function summary

MAGEH1 is implicated in cellular processes such as cell cycle regulation and apoptosis. Researchers know that it may interact with other proteins forming part of a larger protein complex. This complex can influence the regulation of gene expression although the exact partners of MAGEH1 in these interactions remain an active area of research. MAGEH1's roles in these cellular processes suggest its involvement in controlling cellular growth and death.

Pathways

Several aspects beyond MAGEH1 indicate its functions within important biological pathways like p53 and the apoptotic pathways. MAGEH1 can interact with proteins such as p53 which is pivotal in the maintenance of genomic stability and cell cycle arrest. These interactions highlight the role of MAGEH1 in apoptosis and cellular response to stress. In addition its interaction with members of the Bcl-2 family further supports its involvement in apoptotic pathways.

Multiple studies link MAGEH1 with cancer and neurodegenerative diseases. In certain cancers overexpression or malfunction of MAGEH1 correlates with tumor progression and poor prognosis. MAGEH1 might interact with E3 ubiquitin-protein ligases like MDM2 which regulates p53 levels and can contribute to tumorigenesis when dysregulated. Research also suggests a potential role in neurodegenerative diseases where altered expression of MAGE family proteins influences neural health.
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Specifications

Form

Liquid

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General info

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Product protocols

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Target data

See full target information MAGEH1
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