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AB271604

Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus)

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(1 Publication)

Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus) is a Human Full Length protein, in the 2 to 824 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

MLT, MALT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase

2 Images
Functional Studies - Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus) (AB271604)
  • FuncS

Supplier Data

Functional Studies - Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus) (AB271604)

Specific activity of ab271604.

SDS-PAGE - Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus) (AB271604)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human MALT1/MLT protein (Active) (DDDDK tag N-Terminus) (AB271604)

SDS-PAGE analysis of 2 μg ab271604.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

DDDDK tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Specific Activity: 40 pmol/min/μg.

Accession

Q9UDY8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride

storage-buffer

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Complementary Products

Primary Antibodies

AB33921

Anti-MALT1/MLT antibody [EP603Y]

KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MALT1/MLT antibody [EP603Y] (AB33921)

  • 0
  • 0
Proteins & Peptides

AB271611

Recombinant Human METTL3 protein (DDDDK tag N-Terminus)

Western blot - Recombinant Human METTL3 protein (Tagged) (AB271611)

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Proteins & Peptides

AB163782

Recombinant Human VISTA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VISTA protein (GST tag N-Terminus) (AB163782)

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  • 0
Proteins & Peptides

AB289749

Recombinant Human PVRIG/CD112R protein

SDS-PAGE - Recombinant Human PVRIG/CD112R protein (AB289749)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ASGRARCTRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFKAWAIFKGKYKEGDTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLPPGIVSGQPGTQKVPSKRQHSSVSSERKEEEDAMQNCTLSPSVLQDSLNNEEEGASGGAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDYSLLLTFIYNGRVVGEAQVQSLDCRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLERGILVASNPRGLFVQRLCPIPISWNAPQAPPGPGPHLLPSNECVELFRTAYFCRDLVRYFQGLGPPPKFQVTLNFWEESHGSSHTPQNLITVKMEQAFARYLLEQTPEQQAAILSLV","proteinLength":"Full Length","predictedMolecularWeight":"93 kDa","actualMolecularWeight":null,"aminoAcidEnd":824,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9UDY8","tags":[{"tag":"DDDDK","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Liquid

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General info

Function

Protease that enhances BCL10-induced activation : acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed : 11262391, PubMed : 18264101, PubMed : 24074955). Mediates BCL10 cleavage : MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed : 11262391, PubMed : 18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed : 11262391, PubMed : 18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed : 31133753). May also have ubiquitin ligase activity : binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed : 14695475).

Sequence similarities

Belongs to the peptidase C14B family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Protease that enhances BCL10-induced activation : acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed : 11262391, PubMed : 18264101, PubMed : 24074955). Mediates BCL10 cleavage : MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed : 11262391, PubMed : 18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed : 11262391, PubMed : 18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed : 31133753). May also have ubiquitin ligase activity : binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed : 14695475).
See full target information MALT1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of inflammation research 14:4329-4345 PubMed34511971

2021

Inhibition of MALT1 Alleviates Spinal Ischemia/Reperfusion Injury-Induced Neuroinflammation by Modulating Glial Endoplasmic Reticulum Stress in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Shutian Zhang,Yufeng Yan,Yongze Wang,Zhaodong Sun,Chengzhi Han,Xinyi Qian,Xiaorong Ren,Yi Feng,Jian Cai,Chunmei Xia
View all publications
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Product promise

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