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Recombinant Human MAP2K1IP1 protein is a Human Full Length protein, in the 1 to 124 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Alternative names=Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, Mp1, PRO2783, MAPKSP1, MAP2K1IP1, LAMTOR3
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Sequence
M G S S H H H H H H S S G L V P R G S H M A D D L K R F L Y K K L P S V E G L H A I V V S D R D G V P V I K V A N D N A P E H A L R P G F L S T F A L A T D Q G S K L G L S K N K S I I C Y Y N T Y Q V V Q F N R L P L V V S F I A S S S A N T G L I V S L E K E L A P L F E E L R Q V V E V S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Recombinant Human MAP2K1IP1 protein is a Human Full Length protein, in the 1 to 124 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Alternative names=Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, Mp1, PRO2783, MAPKSP1, MAP2K1IP1, LAMTOR3
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Predicted molecular weight
15.8 kDa
- Amino acids
1 to 124
- Sequence
M G S S H H H H H H S S G L V P R G S H M A D D L K R F L Y K K L P S V E G L H A I V V S D R D G V P V I K V A N D N A P E H A L R P G F L S T F A L A T D Q G S K L G L S K N K S I I C Y Y N T Y Q V V Q F N R L P L V V S F I A S S S A N T G L I V S L E K E L A P L F E E L R Q V V E V S
- Accession
- Q9UHA4-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Specifications
- Form
Liquid
- Additional notes
ab102022 was purified using conventional chromatography techniques.
General info
- Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
- Sequence similarities
Belongs to the LAMTOR3 family.
- Subcellular localisation
Late endosome membrane
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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